Epigenetics of Aging

2010
ISBN: 978-1-4899-8310-7
Verlag: Springer

Buch, Englisch, 469 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 733 g

Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research.

The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins.

Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.

Zielgruppe

Research

Autoren/Hrsg.

Tollefsbol, Trygve O.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Wachstum, Entwicklung, Altern
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik

Inhaltsverzeichnis

TABLE OF CONTENTS

1. Epigenetics and the Aging Process
Trygve O. Tollefsbol

PART I: DNA Methylation and Histone Modifications in Aging

2. Age-related Genomic Hypomethylation
Igor P. Pogribny and Boris F. Vanyushin
3. Gene-specific Hypermethylation in Aging
Adebayo D. Akintola and Alan K. Parrish
4. Aging and Non-sirtuin Histone Modifications
Inga Kadish
5. Sirtuins and Aging
Yuqing Dong and Sige Zou
6. Chromatin in Senescent Cells: a Conduit for the Anti-aging effects of Wnt-signaling?
Gowrishankar Banumathy and Peter D. Adams

7. S-AdenosylMethionine: Simple Agent of Methylation and Secret to Aging and Metabolism?
Wil A.M. Loenen

PART II: Other Epigenetic Processes and Aging

8. Polycomb Group of Genes and the Epigenetics of Aging
Krishnaveni Mishra and Rakesh K. Mishra
9. Chromosomal Position Effect and Aging
Eric Gilson and Frederique Magdinier
10. Noncoding RNA for Pre-symptomatic Diagnosis of Age-dependent Disease
Eugenia Wang

PART III: Impact of Epigenetics on Aging

11. Telomerase Control by Epigenetic Processes in Cellular Senescence
Huaping Chen and Trygve O. Tollefsbol
12. Telomeres, Epigenetics and Aging
J. Arturo Londono-Vallejo
13. Contributions of Tumor Suppressors to the Epigenetic Regulation of Aging Cells
Pinaki Base, Amudha Ganapathy, and Karl Riabowol
14. Epigenetic Drift and Aging
Ester Lara, Vincenzo Calvanese, and Mario F. Fraga
15. Role of Epigenetics in Age-related Long-term Memory Loss
J. Tyson DeAngelis and Trygve O. Tollefsbol

PART IV: Epigenetics of Age-related Diseases

16. The Epigenetics of Age-related Cancers
Kristen H. Taylor, Lynda B. Bennett, Gerald L. Arthur, Huidong Shi, and Charles W. Caldwell
17. DNA Methylation and Alzheimer’s Disease
Thomas van Groen
18. DNA Methylation, Age-related Immune Defects, and Autoimmunity
Jorg J. Goronzy, Guangjin Li, and Cornelia M. Weyand
19. Epigenetic Silencing of Progeroid Syndromes
Ruben Agrelo
20. DNA Methylation and Osteoarthritis
Helmtrud I. Roach

PART V: Epigenetic Interventions and Aging

21. Histone Modifying Drugs in Aging
Ulrich Mahlknecht and Barbara Zschoernig
22. Dietary Effect on Epigenetics During the Aging Process
Yuanyuan Li and Trygve O. Tollefsbol
23. Environmental Effects on Age-related Epigenetics
Sabita N. Saldanha, Ashley McCollum, and Trygve O. Tollefsbol

PART VI: Future Directions/Perspectives

24. Future Directions in Research on the Epigenetics of Aging
Huidong Shi and Charles W. Caldwell
25. Perspectives in Aging and Epigenetics
Robin Holliday