AMP-activated Protein Kinase

1. Auflage 2016
ISBN: 978-3-319-43587-9
Verlag: Springer International Publishing

Buch, Englisch, Band 107, 523 Seiten, HC runder Rücken kaschiert, Format (B × H): 160 mm x 241 mm, Gewicht: 9221 g

Reihe: Experientia Supplementum

AMPK has emerged as an important integrator of signals that control energy balance through the regulation of multiple biochemical pathways in eukaryotes.

This book focuses on the implications of AMPK as a master metabolic regulator in diseases, including new methods and animal models. The contributions are written by leading experts in the field and give an extensive overview of the current knowledge of AMPK biology and the role of AMPK in health and disease.

Zielgruppe

Research

Autoren/Hrsg.

Viollet, Benoit

Cordero, Mario D.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Physiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Biochemie (med.)
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Stoffwechselstörungen

Inhaltsverzeichnis

Part I: AMPK in health.- Structure and Regulation of AMPK.- AMPK Regulation of Carbohydrate Metabolism.- AMPK Regulation of Lipid Metabolism.- AMPK Regulation of Protein Metabolism.- AMPK Regulation of cell growth, apoptosis, autophagy and bioenergetics.- AMPK Regulation of immunology.- AMPK and Stem Cells.- Part II: AMPK in the diseases.- AMPK in metabolic diseases.- AMPK in neurodegenerative diseases.- AMPK in cardiovascular diseases.- AMPK in cancer.- AMPK in aging.- AMPK in musculoskeletal diseases and pain.- AMPK in pathogens.- Part III: Pharmacology of AMPK.- Metformin, new drugs and AMPK.- Small molecules and AMPK.- Nutraceutical compounds and AMPK.- Part IV: Methods of study in AMPK.- Animal models.- In vitro study methods.

Über Autor(innen)

Mario D Cordero is Research Associate at the University of Sevilla, Laboratory of Biological Research. He studies the role of AMPK in the metabolic abnormalities of the central nervous system in psychiatric diseases, and the implication of AMPK in the mechanism of pain and inflammation. He is also involved in drug trials using AMPK activators in rare diseases.





Benoit Viollet leads a research team at the Institut Cochin, Paris, which studies the physiological role of AMPK in cellular energy balance and the integrated stress response such as exercise, as well as nutrient and hormonal signals. The work includes studies of the therapeutic opportunity of AMPK in metabolic abnormalities associated with type 2 diabetes and obesity.