Antigen Presentation

1. Auflage 2012
ISBN: 978-3-642-72047-5
Verlag: Springer

Buch, Englisch, 244 Seiten, Format (B × H): 155 mm x 235 mm, Gewicht: 400 g

Reihe: Current Topics in Microbiology and Immunology

Antigen presentation is central to the immune response, andis instrumental in ensuring that the response mounted is that best suited to the eradication of the particular microbe faced. In this volume, experts in the field provide state-of-the-art descriptions of the antigen presentation pathways. How do viruses disrupt these critical pathways, and to what effect? Do all tissues present antigen in the same way? If not, why? What are the consequences of dysfunctional antigen presentation, seen in certain genetic disorders? This book considers not only the molecular details, but also their relevance to the whole organism.

Zielgruppe

Research

Autoren/Hrsg.

Whitton, J. Lindsay

Inhaltsverzeichnis

An Overview of Antigen Presentation and Its Central Role in the Immune Response.- How Do Endogenous Proteins Become Peptides and Reach the Endoplasmic Reticulum.- Molecular Requirements for Assembly and Intracellular Transport of Class I Major Histocompatibility Complex Molecules.- Peptide-Major Histocompatibility Complex Class I Complex: From the Structural and Molecular Basis to Pharmacological Principles and Therapeutic Applications.- Immune Response of ?2-Microglobulin-Deficient Mice to Pathogens.- CNS Neurons: The Basis and Benefits of Low Class I Major Histocompatibility Complex Expression.- Suppression of MHC Class I Antigen Presentation by Human Adenoviruses.- Herpesvirus Evasion of the Immune System.- Intracellular Transport of Molecules Engaged in the Presentation of Exogenous Antigens.- Biologic Consequences of Defective Major Histocompatibility Complex Class II Presentation.