Pharmacogenomics

From Discovery to Clinical Implementation
Erscheinungsjahr 2023
ISBN: 978-0-443-15336-5
Verlag: Elsevier Science

Buch, Englisch, 390 Seiten, Format (B × H): 237 mm x 191 mm, Gewicht: 790 g

Pharmacogenomics: From Discovery to Clinical Implementation is a complete reference aimed at building a solid foundation of the key concepts in this fast-moving knowledge area. The book's chapters over the foundational aspects of pharmacogenomics, including drug metabolism, drug discovery, development, and testing, and then detail studies of key health conditions and the potential therapeutic applications of pharmacogenomics. Diseases covered include diabetes, cardiovascular diseases, psychiatric disease, cancer, pulmonary and respiratory diseases, viral diseases, gastroenterology, autoimmune diseases, immunosuppressants, and, finally, an overview of computational resources. This is the perfect resource for pharmaceutical science graduate students to learn the key concepts of the area. However, researchers and graduate students in the related fields of genetics, pharmacoepidemiology, molecular biology, and medicinal chemistry will also benefit from the structured approach of the book.

Autoren/Hrsg.

Ahmad Ganie, Showkat

Ali, Aarif

U Rehman, Muneeb

Arafah, Azher

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer

Inhaltsverzeichnis

Part I: Fundamentals 1. Basics of Pharmacogenomics 2. Pharmacogenomics in Drug metabolism 3. Pharmacogenomics in Drug discovery and development 4. Pharmacogenetic Testing

Part II: Therapeutics 5. Pharmacogenomics and Diabetes 6. Pharmacogenomics in Cardiovascular diseases 7. Pharmacogenomics in Psychiatric diseases 8. Pharmacogenomics in Cancer 9. Pharmacogenomics of Pulmonary and Respiratory diseases 10. Pharmacogenomics in Viral Diseases 11. Pharmacogenomics in Gastroenterology 12. Pharmacogenomics in autoimmune diseases 13. Pharmacogenomics of Immunosuppressants 14. Computational and Pharmacogenomic Resources

Über Autor(innen)

U Rehman, Muneeb
Muneeb U Rehman (Ph.D.) is a Faculty member at College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. He holds a doctorate in Toxicology (specialization in cancer biology and natural product research) from Jamia Hamdard, New Delhi, India. Dr. Rehman has more than 10 years of research and teaching experience in the field of toxicology, cancer biology, natural product pharmacology and pharmacogenomics. He is the recipient of several national and international fellowships and awards. He has published more than 100 research papers in peer-reviewed, international journals, and has 5 edited books and 30 book chapters. Dr. Rehman is on the editorial boards and is a reviewer of several high-impact, international scientific journals. He is also a life member of various international societies and organizations. Currently, Dr. Rehman is engaged in studying the molecular mechanisms of cancer prevention by natural products and the role of pharmacogenomics and toxicogenomics in evaluating the effectiveness and safety of drugs.

Ahmad Ganie, Showkat
Showkat Ahmad Ganie (Ph.D.) is currently working as Assistant Professor at Department of Clinical Biochemistry, School of Biological Sciences, University of Kashmir, Srinagar, J&K, India. His area of research is focused on various horizons of plant biochemistry and its application in human health. Dr. Ganie has keen interest in free radical biology, oxidative stress, inflammation, diabetes, cancer biology, therapeutic targets, and medicinal plant-based research. His research team work hard for elucidating/verifying various pharmacological properties of traditionally claimed medicinal herbs. His current research highlights the role of enzyme like protein kinases in regulating hyperlipidaemia. Dr. Ganie is exploring plant compounds that could modulate such kinases and ameliorate diseases associated with hyperlipidaemia. We also evaluate the role of various inflammatory markers in the pathology of inflammation and related disorders. Dr. Ganie is also engaged in exploring various epigenetic mechanisms involved in chromatin dynamics and remodelling, implicated in various human pathologies.

Arafah, Azher
Azher Arafah works in the Department of Clinical Pharmacy, College of Pharmacy at King Saud University in Riyadh, Saudi Arabia.

Ali, Aarif
Aarif Ali (Ph.D.) has recently completed Doctor of Philosophy in Clinical Biochemistry at University of Kashmir and has collaboratively worked and published research papers in different reputed National as well as International journals. He has obtained his BSc from SP College affiliated with University of Kashmir, MSc from University of Kashmir (J&K, India) respectively. Dr. Ali is reviewer of several journals like Plant Cell Biotechnology and Molecular Biology (PCBMB), Current Journal of Applied Science and Technology and Asian Journal of Advances in Medical Science.