Non-Invasive Monitoring of Transdermal Drug Delivery

1. Auflage 2022
ISBN: 978-0-367-76598-9
Verlag: Taylor & Francis Ltd (Sales)

Buch, Englisch, 202 Seiten, Format (B × H): 156 mm x 234 mm, Gewicht: 463 g

The book presents an innovative technology based on injection of a very weak current to trace the quantity of a drug carried immediately after the administration. The book makes the reader familiar with the technology, from the conception through the design of the instrument, up to the preliminary clinical applications. In the first chapter, the method of transdermal drug delivery and the use of impedance spectroscopy in the dermatological field are presented. The second chapter describes a screening measurement campaign aimed at proving the feasibility of the assessment method and identifying the bandwidth of interest. The prototyping, validation and characterization of an instrument to measure the amount of drug delivered (DUSM: Drug Under Skin Meter) are presented in chapter three. In the fourth chapter three experimental campaigns, based on the electrical analysis of the biological tissue behavior due to the drug delivery, are reported: (i) laboratory emulation on eggplants, (ii) ex-vivo tests on pig ears, and finally (iii) in-vivo tests on human volunteers. In the fifth chapter a behavioral model, based on Finite Elements and Partial Differential Equation, of an impedance-based measurement system for assessing the drug released under the skin, during transdermal delivering, is proposed. The last chapter is dedicated to present a campaign in order to prove the suitability for insulin therapy applications. This book is intended for biomedical engineers, biomedical engineering students, operators working in the field of biomedical instrumentation, biotechnologists, and technicians of transdermal vehiculation.

Zielgruppe

Academic

Autoren/Hrsg.

Arpaia, Pasquale

Cesaro, Umberto

Moccaldi, Nicola

Sannino, Isabella

Fachgebiete

• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie Medizinische Biotechnologie
• Technische Wissenschaften Energietechnik | Elektrotechnik Elektrotechnik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizintechnik, Biomedizintechnik, Medizinische Werkstoffe
• Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

Part I. Background. 1. Basic Concepts. Part II. Methods and Instrumentation. 2. Measurement method for aesthetic medicine. 3. Hyaluronic acid meter. 4. Measurement method for diabetology. 5. Insulin Meter. 6. Measurement method for orthopaedics. Part III. Case Studies. 7. Aesthetics medicine. 8. Diabetology. 9. Orthopaedics.

Über Autor(innen)

Pasquale Arpaia is Team Leader at European Organization for Nuclear Research (CERN).

Umberto Cesaro is currently an Adjunct Professor and a Graduate Engineer with the University of Naples Federico II.

Nicola Moccaldi is a Research Fellow with CRdC Tecnologie Scarl, Naples, Italy.

Isabella Sannino works at Cranfield University (England) in Mechatronic Laboratory of Advanced Vehicle Engineering Centre focusing on driver’s neuromuscular dynamics.