Extrachromosomal DNA in Cancer

Mechanisms, Biomarkers, and Therapeutic Implications
1. Auflage 2026
ISBN: 978-1-041-10483-4
Verlag: CRC Press

Buch, Englisch, 224 Seiten, Format (B × H): 178 mm x 254 mm

This book provides a comprehensive review of the emerging role of extrachromosomal DNA (ecDNA) in cancer, highlighting its significance in tumor progression, oncogene amplification, drug resistance, and clinical applications. It explores the structural and functional characteristics of ecDNA, emphasizing its role in shaping the genetic and epigenetic landscapes of cancer cells. The book discusses the impact of ecDNA on tumor heterogeneity, metastasis, and immune evasion, providing insights into how ecDNA contributes to cancer evolution and therapeutic resistance. The book also examines cutting-edge imaging techniques, computational approaches, and non-invasive diagnostic applications of ecDNA, highlighting its potential as a biomarker in precision oncology. Additionally, it presents the novel therapeutic strategies targeting ecDNA, addressing challenges and opportunities in integrating these insights into cancer treatment.  1) Explores the structural formation and oncogenic role of ecDNA in tumor development and progression.

2) Discusses the influence of ecDNA on gene expression, epigenetics, and immune modulation in cancer.  3) Examines the role of ecDNA in drug resistance, metastasis, and disease recurrence. 4) Highlights advanced imaging, computational tools, and non-invasive diagnostic applications of ecDNA.

5) Reviews emerging therapeutic strategies targeting ecDNA for improved cancer treatment and personalized medicine. This book is intended for researchers and students of cancer biology, molecular biology, and biotechnology.

Zielgruppe

Professional Reference

Autoren/Hrsg.

Ashique, Sumel

Madan, Ayush

Debnath, Biplab

Zengin, Gokhan

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pflege Fachpflege
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie
• Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)

Inhaltsverzeichnis

Chapter 1 Overview of ecDNA: Discovery and Emerging Significance in Cancer. Chapter 2 Formation and Structure of ecDNA in Cancer Cells. Chapter 3 ecDNA in Oncogene Amplification and Tumor Progression. Chapter 4 Gene Expression and Epigenetic Landscapes of ecDNA in Cancer. Chapter 5 EcDNA: Role in Cancer Drug Resistance. Chapter 6 Imaging, Visualization and characterization of ecDNA in Cancer Cells. Chapter 7 Extrachromosomal DNA in Non-Invasive Cancer Diagnostics. Chapter 8 Extra-chromosomal DNA (ecDNA) as Diagnostic Biomarkers for Cancers. Chapter 9 ecDNA Knowledge for Personalized Medicines. Chapter 10 ecDNA formation: Tumor Immune Escape. Chapter 11 The Role of ecDNA in Tumor Heterogeneity and Evolution. Chapter 12 Role of ecDNA in Cancer Metastasis and Disease Recurrence. Chapter 13 Computational Approaches to Study EcDNA in Cancer Genomics. Chapter 14 ecDNA and Immune Modulation: Progress and Challenges of Cancer Immunotherapy. Chapter 15 Extrachromosomal DNA (ecDNA) and Clinical Implications in Cancer. Chapter 16 Targeting ecDNA: Novel Therapeutic Approach.

Über Autor(innen)

Sumel Ashique has been working as an assistant professor at Department of Pharmaceutical Technology, Bharat Technology, West Bengal-711316, India. He has 4 years of teaching experience. He has achieved 80 publications of International and national accredited reputed journals. He has knowledge in drug delivery, nanotechnology and targeted treatment strategy. He is working as potential reviewer in many well-known publishers (Elsevier, Springer, Dove Press, and Bentham Sc.). He has also 5 granted patents from IP and Australia, 20 published book chapters in Bentham, Springer, Elsevier, Bentham and Taylor & Francis. Currently is editing 14 books under CRC Press, Elsevier, Taylor and Francis, Wiley, Nova Science and Springer. He has published 80+ papers including research, reviews, column article, editorial in Scopus, WoS indexed. He is serving as guest editor in JoVE journal (IF 1.2, Scopus & WOS indexed), Current Probiotics (Bentham Science) & Current Indian Science Journal. He is a potential reviewer in Elsevier, springer, Taylor & Francis and wiley journal for the expertise in the field of targeted drug delivery, nanotechnology, gut-microbiome, postbiotics. Currently he is pursuing his PhD degree from Lovely Professional University, Punjab, India (NAAC A++) in the Pharmaceutical Science department.

Ayush Madan is an Assistant Professor in the Department of Biotechnology at People’s University and a Graduate Research Assistant at Universiti Malaysia Terengganu. He holds an M.Tech. in Biotechnology from Graphic Era University and has extensive expertise in microbial technology and environmental bioremediation. He has also completed his Ph.D. work in the field of Nanobiotechnology where he has studied the cytotoxic effects of silver and gold nanoparticles on human cells with special reference to chromosomal aberrations. He has published numerous research and review articles in national and international journals and has presented his work at various conferences. He has also served as an editor in 14 books in prestigious publishing house including Taylor and Francis, CABI, Cambridge Scholars, Wiley Scrivener, etc. Previously, he was an Assistant Professor at Shobhit Institute of Engineering and Technology and completed a six-month internship at Biocon Research Limited. His current research involves integrated microalgae-shrimp cultivation for wastewater treatment and shrimp growth enhancement.

Dr. Biplab Debnath is a distinguished Principal and Professor at Bharat Technology, Uluberia, Howrah, West Bengal. His research expertise lies in silico synthesis and biological activities of novel heterocyclic molecules. He has made significant contributions to the field, publishing: 60+ research and review papers in esteemed journals, 02 granted patents,05 book chapters and 8 books with various publishing houses. Dr. Debnath is a dedicated mentor, guiding: 18 M.Pharm scholars, 08 Ph.D. students under his supervision He serves on numerous advisory boards for scientific journals and is a member of several scientific associations. Dr. Debnath has also chaired sessions and presented as a resource person at prestigious international and national conferences. Recent Awards and Recognition Excellence in Pharmaceutical Education and Research award 2024 from Bioequivalence Study Centre, Jadavpur University, and ABS Clinical Solution Best Young Principal Award in Global Leadership Awards 2024, Dubai, from Pharmaceutical Royal International Society (PRISAL) Dr. Debnath's achievements and contributions to pharmaceutical education and research are truly commendable.

Gokhan Zengin is a full Professor of Biology at Selcuk University, He received his biologist diploma from University of Selcuk (2007) and his PhD degree (2015) in Selcuk University. His research activity is documented by more than 900 scientific peer-reviewed papers, and about the same number of conferences and communications to scientific and industrial meetings, 4 books and 10 book chapters. His main research interests have focused on chemical characterization, biological activities innovative and sustainable extraction and processing techniques of natural products.