Buch, Englisch, 320 Seiten, Format (B × H): 236 mm x 184 mm, Gewicht: 680 g
ISBN: 978-1-119-04225-9
Verlag: John Wiley and Sons Ltd
Fachgebiete
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Autismus und Asperger-Syndrom
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Medizinische Mikrobiologie & Virologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
- Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft
- Naturwissenschaften Biowissenschaften Biowissenschaften Ökologie
- Geowissenschaften Umweltwissenschaften Angewandte Ökologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Umweltfaktoren in der Medizin
Weitere Infos & Material
Acknowledgments xi
Prologue xiii
1 Introduction to Autism Spectrum Disorders 1
Smell of Autism 5
The Roundup(TM) Conundrum 7
Testosterone and Male Gender Bias 9
Connecting the Dots 12
Why Is There a "Spectrum" in Autism? 20
Are Genetic Mutations the Cause of Autism? 23
ASD Parent and Affected Child Exome Sequencing Display
De Novo Mutation 23
More Than 1,000 Genetic and Genomic Disorders and Still Counting 24
Why Do Certain Chemicals Induce Specific Depletions of
Certain Brain Compartments? 30
Genesis of an ASD Brain 31
Pinpointing Critical Steps Where the Autistic Brain Emerges 32
Is Finding Mutations the Path to Discovering the Genesis of ASD? 34
Does Brain Size Matter? 36
How Autism Develops in a Fetal Brain 36
Why Is There a "Spectrum" in ASD? 39
ASD and Vaccines 41
Thimerosal Containing Mercury Stays in the Body and Is Very Toxic 42
Summary 43
References 43
2 What is Autism? 51
Legacy of Autism 51
A Short History of Autism 53
DSM?]5 and the ASD Spectrum 60
Changes in ASD diagnosis approved by the APA 61
The impact of the Recent DSM?]5 Changes on Diagnosis and Support Practices 61
A New ASD Diagnosis Category: Social Communication Disorder 62
ASD or a Giant Spectrum of Socioneuropsychological Disorders 62
Asperger Syndrome 63
Pervasive Developmental Disorder Not Otherwise Specified 63
Autistic Disorder 64
Rett Syndrome 64
Childhood Disintegrative Disorder 64
Is Autism a Genetic Disease? 65
Synthetic Chemicals Lack Coevolutionary Adaptation 66
Myth of the Genetic Origin of Autism 67
Phenotypic Heterogeneity in Autism 67
Why Fragile X Syndrome or Tuberous Sclerosis Should Not Be Included in ASD 70
Tuberous Sclerosis 71
Is Finding Mutation the Path to Discovering the Origin of ASD? 72
How Quickly Does Human DNA Mutate? 73
What is the Mutation Rate in the Whole Human Genome? 74
Does Brain Size Matter? 74
Genetics versus Environment 75
References 77
3 Olfaction and Autism 83
How Do We Smell? 87
Summary and Conclusions 92
References 92
4 Oxytocin, Arginine Vasopressin and Autism Spectrum Disorder 97
Oxytocin 97
Why Oxytocin Therapy May be Important for ASD? 99
Hormones, Neuropeptide Arginine Vasopressin and
Oxytocin in ASD 102
Development of Oxytocin and AVP Neurons in Various
Animals and in Man 103
Oxytocin and Social Experience in Development 104
Oxytocin and Developmental Neurological Disorders 106
Exogenous Oxytocin Treatments in Humans 108
Intranasal and Intravenous Oxytocin Studies in ASD 109
Oxytocin Trials in ASD: Beyond the Hype and Hope 110
Summary and Conclusions 112
References 113
5 Male Gender Bias and Levels of Male Hormones During Fetal
Development 123
Association between 2D:4D Ratio and Brain Connection
Development 129
Male and Female Estrogen and Testosterone Hormone Regulations 130
Are there Synthetic Chemicals that Humans Are Not Evolutionarily Exposed To? 130
Why Male Gender Bias? 131
Male and Female Brains in a Test Tube 132
Effects of Three Different Levels of Testosterone on Neuronal Morphology 133
Molecular Basis of Gender Bias in ASD 134
References 136
6 Maternal Twins and Male Gender Bias in Autism Spectrum Disorders 143
The Conundrum of ASD Discordance in Maternal Twins 146
Role of Environment in Maternal Twins revealed by Numerous Methods under Many Conditions 149
What Types of Discordance are Observed in Maternal Twins? 149
Differences in Frontal and Limbic Brain Activation in Monozygotic Twin Pairs Discordant for Severe Stressful Life Events 150
Structural Connectivity of the Brain of a Child with ASD and That of the Unaffected Identical Twin 150
Differences in Genomic and Epigenomic Expression in Monozygotic Twins Discordant for Rett Syndrome 150
Differences in CNV between Discordant Monozygotic Twins with Congenital Heart Defects 151
History of
