Epigenetic Contributions in Autoimmune Disease

2011. Auflage 2011
ISBN: 978-1-4419-8215-5
Verlag: Springer Us

Buch, Englisch, Band 711, 182 Seiten, Format (B × H): 187 mm x 263 mm, Gewicht: 533 g

Reihe: Advances in Experimental Medicine and Biology

This volume focuses on the relevance of epigenetic mechanisms in autoimmune disease. It provides new directions for future research in autoimmune disease.

Zielgruppe

Research

Autoren/Hrsg.

Ballestar, Esteban

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik

Inhaltsverzeichnis

AN INTRODUCTION TO EPIGENETICS.- CHROMATIN MECHANISMS REGULATING GENE EXPRESSION IN HEALTH AND DISEASE.- EPIGENETIC CONTROL OF LYMPHOCYTE DIFERENTIATION.- EPIGENETIC CONTROL IN IMMUNE FUNCTION.- DNA METHYLATION AND B-CELL AUTOR EACTIVITY.- ENVIRONMENTAL AGENTS AND AUTOIMMUNE DISEASES.- EPIGENETIC DYSREGULATION OF EPSTEIN-BARR VIRUS LATENCY AND DEVELOPMENT OF AUTOIMMUNE DISEASE.- DOES GENOMIC IMPRINTING PLAY A ROLE IN AUTOIMMUNITY?.- A NEW EPIGENETIC CHALLENGE: SYSTEMIC LUPUS ERYTHEMATOSUS.- EPIGENETIC DEREGULATION IN RHEUMATOID ARTHRITIS.- PROSPECTS FOR EPIGENETIC COMPOUNDS IN THE TREATMENT OF AUTOIMMUNE DISEASE.- PROFILING EPIGENETIC ALTERATIONS IN DISEASE.

Über Autor(innen)

ESTEBAN BALESTAR is head of the Chromatin and Disease Group at the Cancer Epigenetics and Biology Programme (PEBC) of the Bellvitge Biomedical Research Institute (IDIBELL ) in Barcelona, Spain. Ballestar obtained his PhD degree from the University of Valencia under the supervision of Prof. Luis Franco, specialising in chromatin and histone modifications (1997). He then worked as a Postdoctoral Fellow at the National Institutes of Health, (Bethesda, MD, USA) in the laboratory of Dr. Alan Wolffe where he investigated associations between elements of the chromatin machinery and methylated DNA. From 2001 to 2008, Esteban Ballestar has worked at the CNIO Cancer Epigenetics Laboratory, in association with Dr. Manel Esteller, where his principal area of research has been the study of the implication of chromatin factors in epigenetic alterations in human cancer. His current research is devoted to the establishment of different mechanisms of epigenetic deregulation in the context of the hematopoietic system in both autoimmune diseases and hematological malignancies.