Buch, Englisch, Band 98, 320 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 522 g
Buch, Englisch, Band 98, 320 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 522 g
Reihe: Handbook of Experimental Pharmacology
ISBN: 978-3-642-75857-7
Verlag: Springer
Zielgruppe
Research
Autoren/Hrsg.
Weitere Infos & Material
1 The Pathology of Asthma: An Overview.- A. Introduction.- B. Methods to Investigate the Pathology of Human Asthma.- C. Bronchial Epithelium and Inflammatory Cells in Asthmatic Patients Between Attacks.- D. Bronchial Epithelial Inflammation During an Asthma Attack.- E. Epithelial Regeneration.- F. Airway Smooth Muscle.- G. Bronchial Glands.- H. Neural Pathways.- I. Nerves and Other Airway Structures.- J. Bronchial Circulation.- K. Leakage of the Bronchial Vascular Bed in Patients with Asthma.- L. Conclusion.- References.- 2 The Contribution of Inflammatory Cells to the Pathogenesis of Asthma.- A. Inflammation and Inflammatory Cells.- B. Pathological Evidence for Inflammation in Asthma.- C. Microvascular Leakage.- D. Neutrophils.- E. Eosinophils.- F. Mast Cells and Basophils.- G. Monocytes and Macrophages (Mononuclear Phagocytes).- H. Platelets.- I. Lymphocytes.- J. Concluding Comments.- References.- 3 Inflammatory Mediators.- A. Introduction.- B. Histamine.- C. Cyclooxygenase Products.- D. Lipoxygenase Products.- E. PAF.- F. Kinins.- G. Adenosine.- H. Complement.- I. Serotonin.- J. Chemotactic Factors.- K. Oxygen Radicals.- L. Conclusions.- References.- 4 Pharmacology of Airway Smooth Muscle.- A. Introduction.- B. E/C Coupling Mechanisms.- C. E/C Uncoupling Mechamisms.- D. Future Trends in the Development of Bronchodilator Drugs.- References.- 5 Neural Mechanisms in Asthma.- A. Introduction.- B. Cholinergic Mechanisms.- C. Adrenergic Mechanisms.- D. NANC Nerves and Neuropeptides.- E. Conclusions.- References.- 6 Pharmacology and Therapeutics of ?-Adrenoceptor Agonists.- A. Introduction.- B. The Molecular Nature of the ?-Adrenoceptor and Its Relationship to Adenylate Cyclase.- C. Density and Distribution of ?-Adrenoceptors in the Lung.- D. Therapeutic Sites ofAction.- E. The Status of ?-Adrenoceptor Function in Asthma.- F. The Importance of ?2-Adrenoceptor Selectivity and Efficacy.- G. Adverse Reactions to ?-Adrenoceptor Agonists.- H. Therapeutic Actions of ?-Agonists.- I. Concluding Remarks.- References.- 7 Pharmacology of Anti-Asthma Xanthines.- A. Introduction.- B. Clinical Use.- C. Mode of Action of Xanthines.- D. Conclusion.- References.- 8 Glucocotricosteroids in Asthma.- A. Mechanism of Action of Glucocorticosteroids.- B. Clinical Use.- C. Future Developments.- References.- 9 Pharmacology of Prophylactic Anti-Asthma Drugs.- A. Cromoglycate and Nedocromil.- B. Ketotifen.- C. Pharmacological Analysis.- References.- 10 Pathophysiology and Pharmacology of Aspirin-Induced Asthma.- A. Introduction.- B. Definition and Main Clinical Features.- C. Pathogenesis.