Microanatomy and Function of the Spleen

Softcover Nachdruck of the original 1. Auflage 2000
ISBN: 978-3-540-66161-0
Verlag: Springer Berlin Heidelberg

Buch, Englisch, Band 151, 96 Seiten, Format (B × H): 155 mm x 235 mm, Gewicht: 184 g

Reihe: Advances in Anatomy, Embryology and Cell Biology

5 Function of Splenic Compartments. 45 5. 1 Splenic White Pulp Compartments during Primary T Cell-Dependent Antibody Responses against Protein Antigens. 46 5. 1. 1 Priming of CD4+ Helper T Cells by Dendritic Cells in the PALS. 46 Summary. 49 5. 1. 1. 1 5. 1. 2 Interaction of Primed CD4+ T Cells with Antigen-Specific B Cells in the PALS and Formation of Extrafollicular Foci. 49 5. 1. 2. 1 Summary. 50 5. 1. 3 Formation of Germinal Centres. 50 5. 1. 3. 1 Summary. 55 5. 1. 4 Localisation of Memory B Cells in the Marginal Zone. 55 5. 1. 4. 1 Summary. 57 5. 2 Function of the Marginal Zone during Primary Antibody Responses against T Cell-Independent Type 2 Antigens. 57 5. 2. 1 Summary. 59 Function of the Red Pulp. 59 5. 3 5. 3. 1 Summary. 61 5. 4 Role of the Spleen in CD8+ Cytotoxic T Cell Responses. 61 5. 4. 1 Summary. 62 The Spleen, Natural Killer Cells 5. 5 and Gamma/Delta T Cells. 62 5. 5. 1 Summary. 63 6 Recirculation of Lymphocytes Through the Spleen. 65 6. 1 Summary. 67 7 The Role of Cytokines and Chemokines in the Development of Splenic Compartments. 69 7. 1 Summary. 72 8 Unsolved Problems of Human Splenic Structure and Function. 73 VI 8. 1 Arterial Blood Supply to the Splenic Follicles and to the Perifollicular Zone. 73. 8. 1. 1 Summary. 74 8.

Zielgruppe

Research

Autoren/Hrsg.

Barth, Peter

Steiniger, Birte

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Anatomie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pathologie, Cytopathologie, Histopathologie

Inhaltsverzeichnis

1 Introduction.- 2 Materials and Methods.- 2.1 Animal Spleens.- 2.2 Human Spleens.- 2.3 Antibodies.- 2.4 Single Staining Procedure for Immunohistology.- 2.5 Double Staining Procedure for Immunohistology.- 2.6 Demonstration of Acid Phosphatase in Cryostat Sections.- 2.7 Demonstration of Alkaline Phosphatase in Cryostat Sections.- 3 Microanatomical Compartments of the Rat Spleen.- 3.1 White Pulp.- 3.2 Red Pulp and Splenic Vessels.- 3.3 Summary.- 4 Microanatomical Compartments of the Human Spleen.- 4.1 White Pulp.- 4.2 Red Pulp and Splenic Vessels.- 4.3 Summary.- 5 Function of Splenic Compartments.- 5.1 Splenic White Pulp Compartments during Primary T Cell-Dependent Antibody Responses against Protein Antigens.- 5.2 Function of the Marginal Zone during Primary Antibody Responses against T Cell-Independent Type 2 Antigens.- 5.3 Function of the Red Pulp.- 5.4 Role of the Spleen in CD8+ Cytotoxic T Cell Responses.- 5.5 The Spleen, Natural Killer Cells and Gamma/Delta T Cells.- 6 Recirculation of Lymphocytes Through the Spleen.- 6.1 Summary.- 7 The Role of Cytokines and Chemokines in the Development of Splenic Compartments.- 7.1 Summary.- 8 Unsolved Problems of Human Splenic Structure and Function.- 8.1 Arterial Blood Supply to the Splenic Follicles and to the Perifollicular Zone.- 8.2 Blood Circulation in the Splenic Red Pulp: Subpopulations of Fibroblasts and their Role.- 8.3 Function of Sheathed Capillaries.- 8.4 Lymphocyte Migration in the Human Splenic White Pulp — A Hypothesis.- 9 Summary.- References.