Biotics and the Gut-Brain Axis in Neurological Disorders

1. Auflage 2025
ISBN: 978-1-032-88239-0
Verlag: Taylor & Francis Ltd

Buch, Englisch, 392 Seiten, Format (B × H): 210 mm x 280 mm

This book reviews the pivotal role of prebiotics, probiotics, and postbiotics in modulating the gut–brain axis, offering insights into their potential therapeutic applications and impact on neurological health. The initial chapters provide a foundational overview of prebiotics and introduce readers to the concept of the gut–brain axis. These chapters discuss bidirectional communication within the gut–brain axis and the impacts of gut dysbiosis on neurological health. Further chapters investigate the relationship between the gut–brain axis and autoimmune diseases, as well as the role of probiotics in major neurodegenerative diseases such as Alzheimer’s and Parkinson’s, amyotrophic lateral sclerosis (ALS), Huntington’s disease, and conditions like multiple sclerosis (MS), epilepsy, and seizures. The book also examines the influence of prebiotics on mental health disorders such as anxiety and depression, and their impact on ischemic stroke via the gut–brain axis. It further covers the role of probiotics in reactive oxygen species (ROS) and inflammation-mediated neurodegenerative diseases and explores the correlation between gut microbiota, malnutrition, and neurological disorders. The book explores signaling pathways within the gut–brain axis and their relationships with neurological disorders, the application of prebiotics as functional foods, and the therapeutic potential of postbiotics and psychobiotics. This book is intended for scientists and researchers in the fields of microbiology, neuroscience, and gastroenterology. The book:

- Provides a thorough understanding of prebiotics, probiotics, and postbiotics, and their roles in the gut–brain axis

- Explores bidirectional communication within the gut–brain axis and its impact on neurological health

- Examines the relationship between the gut microbiota and various neurological disorders

- Discusses the influence of prebiotics and probiotics on mental health disorders such as anxiety and depression

- Investigates the connection between the gut–brain axis and autoimmune diseases

- Covers advanced tools and bioinformatics approaches for studying gut microbiota and neurodegeneration

Zielgruppe

Academic, Postgraduate, and Professional Reference

Autoren/Hrsg.

Bhowmick, Mithun

Mishra, Neeraj

Ashique, Sumel

Fachgebiete

• Naturwissenschaften Biowissenschaften Mikrobiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft

Inhaltsverzeichnis

Acknowledgment

Preface

About the Editors

Chapter 1 Prebiotics: General Overview, Characteristics, and Application in Health Benefits

Ayush Madan, Rahul Kumar, Pranshul Sethi, and Debasis Mitra

Chapter 2 Introduction to the Gut–Brain Axis

Ashish Garg, Abhavya Shukla, Sweta Garg, Prakash Pandey, Vishal Singh, and Gopal Rai

Chapter 3 Introduction and Overview of Prebiotics, Probiotics, and Postbiotics

Phool Chandra, Nishat Fatma, and Neetu Sachan

Chapter 4 Bidirectional Communication in the Gut–Brain Axis

Priya Chaudhary, Divya Kumari, Apurva, Narotam Sharma, and Pracheta Janmeda

Chapter 5 Gut Dysbiosis and Its Impact on Neurological Health

Hari Om, Kavita, and Pramod Kumar Kushwaha

Chapter 6 Connection between Gut Microbiota and Neurodegenerative Diseases

Aniruddha Sen, Vijay Singh, Bidisha Halder, Sapna Saini, Sumel Ashique, Radheshyam Pal, Sabina Yasmin, and Mohammad Yousuf Ansari

Chapter 7 Gut Microbiota in Mental Health Disorders

Saikat Santra, Rajdip Goswami, Bhaskar Pal, Subhajit Das, and Ayan Chatterjee

Chapter 8 Gut–Brain Axis and Autoimmune Diseases: Correlation between Both

Devid Chutia, Jadab Rajkonwar, and Srijita Chakrabarti

Chapter 9 Signaling Events from the Gut: Regulate Brain Function and Its Link to Autoimmune Disorders

Gagandeep Kaur, Parul Sood, Shabnam, Rupesh K. Gautam, and Nitin Jangra

Chapter 10 Role of Probiotics in Alzheimer’s Disease and Parkinson’s Disease

Mohsin Vahid Khan, Mohd Rumman, Anas Islam, Mohd Kamil Hussain, and Gulam Rabbani

Chapter 11 Role of Probiotics in Amyotrophic Lateral Sclerosis (ALS) and Huntington’s Disease

Mirunalini Gobinath, L Priyanka Dwarampudi, Shanmugam R, Subhajit Dutta, Parikshit Roychowdhury, and Swati Swagatika Swain

Chapter 12 Role of Probiotics in MS, Epilepsy, and Seizures

Kajal Gurow, Deepak Chandra Joshi, Uttam Singh Baghel, and Lata Bish

Chapter 13 Role of Probiotics in Anxiety and Depression

Mirunalini G, L Priyanka Dwarampudi, Shanmugam R, Parikshit Roychowdhury, and Subhajit Dutta

Chapter 14 Role of Probiotics and Prebiotics in Ischemic Stroke in Connection with the Gut–Brain Axis

Aarti Gupta, and Alankar Shrivastava

Chapter 15 Role of Probiotics

Divya Kumari, Ayush Madan, Priya Chaudhary, and Pracheta Janmeda

Chapter 16 Correlation between Gut Microbiome and Malnutrition and Other Factors in Neurological Disorders

Manikandan Gurusamy

Chapter 17 Tools and Bioinformatic Approaches to Study Gut Microbiota and Neurodegeneration

Rideb Chakrabortya, Naureen Afrose, Pratibha Bhowmick, and Mithun Bhowmick

Chapter 18 Brain–Gut Axis Focusing on High-Throughput Technologies Like Gene Sequencing, Brain Imaging, and Metabolomics

Vaibhav Dagaji Aher, Abhishek Sharma, Simanchal Panda, Krishna Chandra Panda, and Pankaj Sharma

Chapter 19 Signaling Pathways and Gut–Brain Axis: Relationship in Neurological Disorders

Papia Acharjee, Vishal Vikram Singh, Shambhu Kumar Prasad, Priyanka Thakur, and Arup Acharjee

Chapter 20 Prebiotic as Functional Food in Neurological Disorder

Pankaj Sharma, Sarvesh Bhargava, Vinay Jain, Deepesh Parashar, and Wasim Akram

Chapter 21 Postbiotics and Psychobiotics: Therapeutic Interventions in Neurodegenerative Diseases

Anas Islam, Badruddeen, Mohammad Irfan Khan, Mohsin Vahid Khan, and Yusuf Asad

Chapter 22 Gut Microbiota-Derived Bacterial Metabolites: Role in Neurological Disorders

Karan Goel, Isha Chawla, Garima, and Meenakshi Dhanawat

Chapter 23 Therapeutic Applications of Prebiotics, Probiotics, and Postbiotics

Surendra Agrawal, Pranita Jirvankar, Sunita Vaidya, Nikhita Chambhare, and Pravina Gurjar

Chapter 24 Nanocarriers Encapsulated Polyphenols, Functional Foods to Modulate Gut Microbiota: In Neurological Disorders

Ameya Sharma, Malkiet Kaur, Divya Dheer, Aditya Gautam, and Vivek Puri

Chapter 25 Probiotics as Nutraceuticals in Neurological Disorders

M. Malarvannan, S. Bhanu Teja Naik, David Paul, Satheeshkumar Nanjappan, and V. Ravichandiran

Chapter 26 Lifestyle and Environmental Factors: Impact on Gut Microbiota and Neurological Disorder

Pooja S Murkute, Saistha Anjum, S. Sowmiya, Arghya Paria, Sourabh Kosey, Naheed Mojgani, and Sumel Ashique

Chapter 27 Prebiotics, Probiotics, and Postbiotics as a Complementary Therapy in the Management of Neurological Disorders: Clinical Trials and Case Studies

Heena¹, Priyanka Rana¹, Monika ¹, Tanzeer Kaur², Neelima Dhingra*

Chapter 28 Application of Artificial Intelligence in Connection with Gut Microbiota to Detect Neurological Disorders

N.L. Swathi, Kashif Raza Siddique, Habiba Babul, Pranjal. Kumar Singh, and Dinesh Kumar

Chapter 29 Future Perspectives and Challenges of Probiotics, Prebiotics, and Postbiotics and Gut–Brain Axis in Neurodegenerative Disorders

Samaresh Pal Roy, Sunil Kumar Kadiri, Suchismita Bhowmik, Vimal Patel, and Lokesh Deb

Chapter 30 Regulatory Concern of Prebiotics, Probiotics, Postbiotics, and Market Growth in India

Soumik Bhattacharjee, Sumit Nandi, Dr Rana Dutta, Dr Amites Gangopadhyay, and Dr Kalyan Kumar Sen

Index

Über Autor(innen)

Neeraj Mishra has been serving as Professor and Head of the Department at the Amity Institute of Pharmacy, Amity University, Gwalior, India, since July 2019. With approximately 20 years of experience in teaching and research, Dr. Mishra has made significant contributions to the field. He has over 125 publications in both international and national journals, focusing on novel drug delivery systems, oral delivery of synbiotics, localized drug delivery, and targeted and controlled delivery of nanocarriers and microparticles for treating breast and colon cancer, as well as neurodegenerative disorders. He has authored more than 15 books and 25 book chapters and holds three international patents and three Indian patents. His achievements have been recognized with several awards, including the “Distinguished Professor Award” from DST-NSTMIS, SPAICS, Indore, in 2019, and the “Outstanding Scientist Award” at the 6th International Scientist Awards on Engineering, Science, and Medicine in 2020. He also received the “Distinguished Professor Award” from the Indian Pharmaceutical Association, MP State Branch, in 2021, and the “Best Academician Award” at the Indian Pharmacy Graduate Association, M.P. State International Conference in 2023.

Sumel Ashique is Assistant Professor in the Department of Pharmaceutical Technology, Bharat Technology, Howrah, India. With five years of teaching experience, he has made notable contributions to his field. He has published more than 100 papers in reputable international and national journals. His expertise includes drug delivery, nanotechnology, and targeted treatment strategies. He also serves as a reviewer for several prestigious international journals. He holds five granted patents from IP Australia, India, and Canada. He has contributed to 20 book chapters and has edited 18 books.

Mithun Bhowmick is Professor and Principal at the Bengal College of Pharmaceutical Sciences & Research in Durgapur, West Bengal, India. He has received numerous prestigious awards throughout his career. Dr. Bhowmick has actively participated in and presented research papers at various international and national conferences. He has published more than 50 research and review papers in esteemed national and international journals. His accomplishments include several patents from Australia, Germany, and India, as well as design patents and copyrights. Dr. Bhowmick is a reviewer for numerous pharmaceutical journals and is a lifetime member of several professional organizations, including the Association of Pharmaceutical Teachers of India (APTI), the Indian Pharmacy Graduates’ Association (IPGA), and the Institute of Scholars (InSc.). He is also a registered fellow member of the Centre for Education Growth and Research (CEGR) in New Delhi.