Bittar Molecular and Cellular Genetics

1. Auflage 1996
ISBN: 978-0-08-053673-6
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 412 Seiten, Web PDF

The tools of molecular biology have revolutionised our understanding of gene structure and function and changed the teaching of genetics in a fundamental way. The transition from classical genetics to molecular genetics was initiated by two discoveries. One was the discovery that DNA has a complementary double helix structure and the other that a universal genetic code does exist. Both led to the acceptance of the central dogma that RNA molecules are made on DNA templates. The last twenty years have seen remarkable growth in our knowledge of molecular genetics, most of which is the outcome of recombinant DNA technology. This technology which is not limited to cloning, sequencing, and expression has created a biotechnology industry of its own, the purpose of which is to develop new diagnostic and therapeutic approaches in medicine. Both industries in collaboration with the biomedical community are now engaged in laying down the foundation of molecular medicine. The present volume seeks to provide a coherent account of the new science of molecular genetics. Its content however is by no means exhaustive, partly because of the publication explosion but more because of space restrictions. A rudimentary knowledge of genetics on the reader's part is assumed. Quite understandably, considerable emphasis is placed on major technical advances but not without expounding numerous new ideas and phenomena including alternative splicing, POR, DNA methylation, genomic imprinting, and so on.

Autoren/Hrsg.

Bittar, Edward

Inhaltsverzeichnis

1;Cover;1
2;Copyright Page;7
3;TOC$Contents;8
4;List of Contributors;12
5;Preface;14
6;CH$Chapter 1. The Nucleosome;16
7;CH$Chapter 2. DNA Replication and its Control;26
8;CH$Chapter 3. DNA Methylation;48
9;CH$Chapter 4. Role of Histones and their Acetylation in Control of Gene Expression;82
10;CH$Chapter 5. Protein-Nucleic Acid Recognition and Interactions;100
11;CH$Chapter 6. Transcription Factors;132
12;CH$Chapter 7. Alternative RNA Splicing;150
13;CH$Chapter 8. Antisense RNA and DNA as Potential Therapeutic Agents;164
14;CH$Chapter 9. Regulation of Gene Expression and Gene Amplification;178
15;CH$Chapter 10. Signal Transduction to the Cell Nucleus;216
16;CH$Chapter 11. DNA Damage and Its Repair;244
17;CH$Chapter 12. The Nature and Significance of Mutations;270
18;CH$Chapter 13. The Polymerase Chain Reaction;286
19;CH$Chapter 14. Molecular Cloning;304
20;CH$Chapter 15. DNA Probes in Human Diseases;322
21;CH$Chapter 16. Advances in Clinical Genetics;346
22;CH$Chapter 17. The Genome Project—A Commentary;360
23;CH$Chapter 18. Transgenic Regulation in Laboratory Animals;392
24;IDX$Index;418