Dendrimers in Medicine and Biotechnology

New Molecular Tools
Erscheinungsjahr 2006
ISBN: 978-0-85404-852-6
Verlag: RSC Publishing

Buch, Englisch, 190 Seiten, Format (B × H): 240 mm x 161 mm, Gewicht: 445 g

Dendrimers are a new class of macromolecule increasingly used in the fields of synthetic organic chemistry, biology, medicine and biotechnology. Dendrimers in Medicine and Biotechnology: New Molecular Tools looks at this exciting and rapidly growing area of science. Using an interdisciplinary approach with particular emphasis on biological applications, the book discusses the relationship between the dendrimer molecular motif and its biological properties. A general introduction to the subject of dendrimers, including definitions of terms and symbols, is provided. Subsequent sections discuss topics including dendrimers in biological systems, dendrimers as drug delivery devices, dendrimers in diagnostics and dendrimer drugs. Throughout the book examples from current research are also provided. This book will appeal to a wide range of scientists, including non specialists who require an introduction to dendrimers, as well as those wishing to know more about the application of dendrimers in the field of biology and medicine.

Zielgruppe

Postgraduate students, academics, libraries, consultants, industrial chemists Bioorganic Chemistry, Polymer Sciences, Medicinal Chemistry, Biochemistry, general

Autoren/Hrsg.

Boas, U.

Christensen, J B

Heegaard, P M H

Weitere Mitwirkende

Peng, Ling

Fachgebiete

• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Technologie der Kunststoffe und Polymere
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie
• Naturwissenschaften Chemie Organische Chemie Biochemie
• Naturwissenschaften Chemie Organische Chemie Polymerchemie
• Technische Wissenschaften Maschinenbau | Werkstoffkunde Technische Mechanik | Werkstoffkunde Materialwissenschaft: Polymerwerkstoffe
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Physik, Chemie, Biologie für Mediziner

Inhaltsverzeichnis

Chapter 1: Dendrimers: Design, synthesis and chemical properties;

1.1: Introduction;

1.2: Terms and nomenclature in dendrimer chemistry;

1.3: Dendrimer design;

1.4: Dendrimer synthesis;

1.5: Physicochemical properties of dendrimers;

1.6: Summary;

Chapter 2: Properties of dendrimers in biological systems;

2.1: Significance of multivalent binding in biological interactions;

2.2: Biocompatibility of dendrimers;

2.3: Summary;

Chapter 3: Dendrimers as drug delivery devices;

3.1: Introduction;

3.2: Dendrimer hosts;

3.3: Covalently bound dendrimer conjugates;

3.4: Dendrimers as gene transfer reagents;

3.5: Summary;

Chapter 4: Dendrimer drugs;

4.1: Introduction;

4.2: Antiviral dendrimers;

4.3: Antibacterial dendrimers;

4.4: Dendrimers in antitumor therapy;

4.5: Dendrimer in therapy of other diseases;

4.6: Dendrimer based vaccines;

4.7: Dendrimer interactions with proteins. Solubilisation of protein aggregates;

4.7: Summary;

Chapter 5: Dendrimers in diagnostics;

5.1: Contrast agents based on dendrimers;

5.2: Fluorescence enhanced by dendrimers;

5.3: Dendrimers in bioassays;

5.4: Summary;

Chapter 6: Dendrimers as biomimics;

6.1: Introduction;

6.2: Deddrimers as protein mimics;

6.3: Dendrimers as artificial enzymes;

6.4: Dendrimers as artificial antigens, antibodies and cell surfaces;

6.5: Summary;

Über Autor(innen)

Boas, Danish Institute for Food and Veterinary Research, Denmark / J B Christensen, University of Copenhagen, Denmark / P M H Heegaard, Danish Institute for Food and Veterinary Research, Denmark