Bioinformatics for Evolutionary Biologists

A Problems Approach
Softcover Nachdruck of the original 1. Auflage 2017
ISBN: 978-3-319-88424-0
Verlag: Springer International Publishing

Buch, Englisch, 318 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 511 g

This self-contained textbook covers fundamental aspects of sequence analysis in evolutionary biology, including sequence alignment, phylogeny reconstruction, and coalescent simulation. It addresses these aspects through a series of over 400 computer problems, ranging from elementary to research level, to enable learning by doing. Students solve the problems in the same computational environment used for decades in science – the UNIX command line. This is available on all three major operating systems for PCs: Microsoft Windows, Mac-OSX, and Linux. To learn using this powerful system, students analyze sample sequence data by applying generic tools, bioinformatics software, and over 40 programs specifically written for this course. The solutions for all problems are included, making the book ideal for self-study. Problems are grouped into sections headed by an introduction and a list of new concepts and programs. By using practical computing to explore evolutionary concepts and sequence data, the book enables readers to tackle their own computational problems.

Zielgruppe

Graduate

Autoren/Hrsg.

Börsch-Haubold, Angelika

Haubold, Bernhard

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften Evolutionsbiologie
• Naturwissenschaften Biowissenschaften Angewandte Biologie Bioinformatik
• Mathematik | Informatik EDV | Informatik Angewandte Informatik Bioinformatik

Inhaltsverzeichnis

The UNIX Command Line.- Constructing and Applying Optimal Alignments .- Exact Matching.- Fast Alignment.- Evolution between Species: Phylogeny.- Evolution within Populations.- Additional Topics.

Über Autor(innen)

Bernhard Haubold studied Natural Sciences at Cambridge University, UK and completed his DPhil in Bacterial opulation Genetics at Oxford University, UK in 1998. After training as a Post-Doc at the Max-Planck-Institute for Chemical Ecology in Jena, Germany he worked in the biotech industry before taking on a professorship in  Bioinformatics at the University of Applied Sciences, Weihenstephan, Germany in 2003. In 2008, he moved to his current post as a researcher at the Max-Planck-Institute for Evolutionary Biology in Plön, Germany. He also teaches Bioinformatics at Lübeck University. Together with Thomas Wiehe he is the author of Introduction to Computational Biology, An Evolutionary Approach, which was published by Birkhäuser in 2006.

Angelika Börsch-Haubold studied Pharmacy at Freiburg University, Germany and Pharmacology at Cambridge University, UK. She completed her DPhil in Pharmacology at Oxford University, UK in 1997, prior to remaining at Oxford for a junior research fellowship. From 2005 to 2008, she taught various courses at the University of Applied Sciences, Weihenstephan, Germany. From 2008 to 2014 she worked as a researcher at the Max-Planck-Institute for Evolutionary Biology in Plön, Germany. She has contributed teaching material to Science in School and was involved in translating the fifth edition of The Molecular Biology of the Cell into German.