The Multitasking Molecular Chaperone Hsp60

Structure, Function, and Impact on Health and Disease
Erscheinungsjahr 2024
ISBN: 978-0-443-23996-0
Verlag: Elsevier Science

Buch, Englisch, 324 Seiten, Format (B × H): 150 mm x 229 mm, Gewicht: 476 g

The Multitasking Molecular Chaperone Hsp60: Structure, Function, and Impact on Health and Disease provides an overview of this key component of the Chaperone System (CS). The book covers various areas of medicine in which Hsp60 chaperonopathies have been identified. Various chapters discuss the Hsp60 structure, localization, functions, and participation in disease mechanisms both genetic and acquired, focusing on humans but also presenting data obtained from pro- and eukaryotic experimental models. The main goal is to provide information accessible to all healthcare professionals in a way that can be understood by nonspecialists and that would stimulate clinical and pathological detection of Hsp60 chaperonopathies.

Molecular mechanisms are briefly described with the purpose of illuminating roads toward accurate diagnosis, treatment, and patient monitoring. Consequently, the possibility of developing/applying chaperonotherapy centered on Hsp60, as a therapeutic tool or target, is analyzed in many sections of this book, across a variety of medical specialties. Over the last several years, the importance of the CS as a physiological system has been brought to prominence and its roles in health and disease made clear. The molecular chaperones, including Hsp60, are the key components of the CS that are typically cytoprotective, but they can also be etiopathogenic factors, causing diseases named chaperonopathies.

Autoren/Hrsg.

Cappello, Francesco

Conway de Macario, Everly

JL Macario, Alberto

Fachgebiete

• Naturwissenschaften Biowissenschaften Molekularbiologie

Inhaltsverzeichnis

- The chaperone system and its diseases: Introductory overview focusing on Hsp60
- Physical and biochemical properties of the molecular chaperone Hsp60
- The spectrum of human Hsp60 genetic variants and associated chaperonopathies
- Hsp60 in inflammation and autoimmunity
- Hsp60 and carcinogenesis
- Hsp60 involvement in cartilage tissue homeostasis and pathogenesis
- Hsp60 and skeletal muscle diseases
- Hsp60 and cardiovascular diseases
- Hsp60 in physiology and pathophysiology of the respiratory system
- Hsp60 and diseases of the digestive system
- The chaperone system and the pathophysiology of the urogenital apparatus: Hsp60 roles
- Hsp60 and nervous system development and diseases
- Hsp60 and pathophysiology of the neuroendocrine system

Über Autor(innen)

Conway de Macario, Everly
Everly Conway de Macario is Adjunct Professor at the School of Medicine, University of Maryland at Baltimore, Baltimore, MD, USA. She has written 320 articles, authored 1 book and edited 8 books. Dr. Conway de Macario's research interests include the development of the concept of sick chaperone or chaperonopathy as a factor contributing to the ageing process and disease, elucidation of the entire set of hsp70 genes in the human genome, and characterization of the whole complement of cct-Hsp60 genes in the human genome.

JL Macario, Alberto
Alberto JL Macario is Adjunct Professor at the School of Medicine, University of Maryland at Baltimore, Baltimore, MD, USA. He has authored 380 articles, is the author of 1 book, and editor of 7 books. Dr. Macario is also Group Leader at the Euro-Mediterranean Institute of Science and Technology, Palermo, Italy. His current interests are chaperonopathies pertaining to Hsp60, Hsp10, and CCT genes/proteins.