Cechinel-Filho Plant Bioactives and Drug Discovery

Principles, Practice, and Perspectives
1. Auflage 2012
ISBN: 978-1-118-25992-4
Verlag: John Wiley & Sons
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 592 Seiten, E-Book

Reihe: Wiley series in drug discovery and development

An in-depth exploration of the applications of plant bioactive metabolites in drug research and development
Highlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives provides an in-depth overview of the ways in which plants can inform drug research and development. An edited volume featuring multidisciplinary international contributions from acclaimed scientists researching bioactive natural products, the book provides an incisive overview of one of the most important topics in pharmaceutical studies today.
With coverage of strategic methods of natural compound isolation, structural manipulation, natural products in clinical trials, quality control, and more, and featuring case studies on medicinal plants, the book serves as a definitive guide to the field of plant biodiversity as it relates to medicine. In addition, chapters on using natural products as drugs that target specific disease areas, including neurological disorders, inflammation, infectious diseases, and cancer, illustrate the myriad possibilities for therapeutic applications.
Wide ranging and comprehensive, Plant Bioactives and Drug Discovery also includes important information on marketing, regulations, intellectual property rights, and academic-industry collaboration as they relate to plant-based drug research, making it an essential resource for advanced students and academic and industry professionals working in biochemical, pharmaceutical, and related fields.

Autoren/Hrsg.

Cechinel-Filho, Valdir

Inhaltsverzeichnis

Chapter 1. Natural products in drug discovery: recents advances
Gordon M. Cragg, Paul G. Grothaus, David J. Newman
Chapter 2. Modern approaches in the search for new active compounds from crude extracts of natural sources
Emerson F. Queiroz, Kurt Hostettmann, Jean-Luc Wolfender
Chapter 3. Natural product as lead compounds in medicinal chemistry
Eliezer J. Barreiro, Carlos A. M. Fraga, Lidia M. Lima
Chapter 4. The importance of structural manipulation of natural compounds in drug discovery and development
Arturo San Feiliciano, Maria Á. Castro, José L. López-Pérez and Esther del Olmo
Chapter 5. The action of plants and their constituents on the central nervous system
Fúlvio R. Mendes, Gina Negri, Joaquim M. Duarte-Almedia, Ricardo Tabach, Elisaldo A. Carlini
Chapter 6. The role of natural products in discovery of new anti-infective agents with emphasis on antifungal compounds
Maximiliano Sortino, Marcos Derita, Laura Svetaz, Marcela Raimondi, Melina Di Liberto, Elisa Petenatti, Mahabir Gupta, Sisana Zacchino
Chapter 7. Antiulcer agent from higher plants
Luiz C. Klein-Júnior, José R. Santin, Sérgio F. de Andrade
Chapter 8. Recent progress in the chemistry and biology of pacilitaxel (Taxol(TM)) and related taxanes
Jun Qi, Jielu Zhao, David G. I. Kingston
Chapter 9. Cancer chemopreventive activity of higher plants
A.Douglas Kinghorn, Yulin Ren, Jie Li, Chung Ki Sung
Chapter 10. Medicinal plants and pharmaceutical technology
Ruth M. Lucinda da Silva, Angélica G. Couto, Tania M. B. Bresolin
Chapter 11. Natural products in clinical trails
Sigrun Chrubasik
Chapter 12. The influence of biotic and abiotic factors on the production on secondary metabolites in medicinal plants
Dayana R. Gouveia, Leonardo Gobbo-Neto, Norberto P. Lopes
Chapter 13. Production of bioactives compounds: the importance of Pictet-Spengler reaction in the XXI Century
Pilar Menendez, Ilaria D'Acquarica, Giuliano Delle Monache, Francesca Ghirga, Andrea Calcaterra, Marco Barba, Alberto Macone, Alberto Boffi, Alessandra Boramore, Bruno Botta
Chapter 14. Screening methods for drug discovery from plants
Alan L. Harvey
Chapter 15. Phytotherapeutics - intellectual property rights, global market, and global regulatory guidelines
James D. McChesney, Raymond Cooper, Kip Vought
Chapter 16. Cooperation between the pharmaceutical industry and academic instiutions in drug discovery
Valdir Cechinel Filho, Rivaldo Niero and Rosendo A. Yunes

Über Autor(innen)

Valdir Cechinel-Filho, PhD, is Professor and Researcherat the Chemical-Pharmaceutical Investigations Center, University ofVale do Itajaí in Brazil. The editor of five books, seventeencontributed chapters, and over 250 scientific papers and reviews,Dr. Filho is also Associate Editor of PharmaceuticalBiology, a member of the editorial boards of several journals,and a reviewer for many journals, including European Journal ofMedicinal Chemistry, Journal of Pharmacy andPharmacology, Natural Product Research, PlantaMedica, and Journal of Agricultural and FoodChemistry.