Cellular Signalling in Cancer Metastasis

Erscheinungsjahr 2019
ISBN: 978-0-12-814193-9
Verlag: Elsevier Science

Buch, Englisch, 300 Seiten, Format (B × H): 191 mm x 235 mm

Cellular Signalling in Cancer Metastasis provides the reader with in-depth information on the cellular signaling mechanisms responsible for cancer metastasis. While significant progress has been made in understanding the mechanisms responsible for metastasis, the lack of a comprehensive book compiling these aspects was necessary, hence the development of this timely resource. This book is intended to help entry level researchers, from graduate students, postdocs and early career scientists, but is detailed enough to be considered by seasoned scientists. It provides the reader with the current knowledge available on the subject and stimulates others to take up investigations on understanding cancer metastasis.

Zielgruppe

<p>cancer researchers, oncologists, graduate students</p>

Autoren/Hrsg.

Weitere Mitwirkende

Zubair, Haseeb

Fachgebiete

• Wirtschaftswissenschaften Wirtschaftssektoren & Branchen Fertigungsindustrie Spitzentechnologiesektor

Inhaltsverzeichnis

1. Clinical standpoint of cancer metastasis2. Motility and tumor invasion in metastasis3. Epithelial and mesenchymal states and their role in cancer metastasis signalling4. Hypoxia-induced cancer metastasis signalling5. Integrins in cancer metastases6. miRNA mediated regulation of cancer metastasis7. The Role of Myeloid-Derived Suppressor Cells in Cancer Progression8. Modulation of endothelial cells for cancer metastasis9. Vascular endothelial growth factor signalling in cancer metastasis10. Wnt signalling in cancer metastasis11. Notch signalling in cancer metastasis12. GLI signalling in cancer metastasis13. Mutant TP53 in cancer metastasis14. CXCR4/CXCL12 in cancer metastasis15. Role of tumor microenvironment in melanoma metastasis16. Cancer secretome in cancer metastasis17. Systems biology of cancer metastasis18. Systems biology of metabolism in cancer metastasis

Über Autor(innen)

Zubair, Haseeb
Dr. Hasseb Zubair's research interest is focused on the signalling pathways that control cancer development and progression. Recently, using a combination of RNA-sequencing and bioinformatics tools he has demonstrated the potential cellular networks perturbed by c-MYB in pancreatic cancer. c-MYB has been identified to exert oncogenic properties to different types of cancer, however the molecular pathways underlying these phenotypes are not completely understood. Dr Zubair's research team are now underway to investigate the role of the c-MYB-modulated signalling pathways in progression and metastasis. In a much recent accomplishment, his research article has been accepted in the journal Cancer Research in which he has demonstrated a novel signalling axis responsible for the stabilization and up regulation of c-MYC transcription factor in pancreatic cancer. In addition, Dr. Zubair has been studying the cancer therapeutic and preventive properties of natural products. He has demonstrated that mobilization of endogenous cellular copper ions by these plant derived antioxidant leads to the generation of reactive oxygen species which act as proximal DNA damaging agents inducing cell death.