Drug Discovery and Development, 2 Volume Set

Revised Auflage
ISBN: 978-0-471-39846-2
Verlag: Wiley

Buch, Englisch, 904 Seiten, Format (B × H): 185 mm x 263 mm, Gewicht: 1828 g

Den langen Weg eines neuen Wirkstoffs von der Entdeckung der chemischen Verbindung bis zum klinischen Einsatz verfolgt dieses zweibändige, ausführliche Werk.
- mit Fallstudien zur Entwicklung von Erythromycin-Analoga, Tagamet und Ultiva (Remifentanil)
- diskutiert werden Wirkstoffe zur Behandlung von bakteriellen Infektionen, der Parkinson-Krankheit, Schuppenflechte, Magenschmerzen und -geschwüren, atopischer Dermatitis, Asthma und Krebs
- enthält Kapitel zur kombinatorischen Chemie, molekularbiologischen Wirkstoffforschung und zur Genomforschung

Autoren/Hrsg.

Chorghade, Mukund S

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Labormedizin

Inhaltsverzeichnis

Bioactive Molecules in Medicinal Plants: A Perspective on their Therapeutic Action / S C Taneja, G N Qazi

Natural Products as an Inspiration for the Discovery of New High-Throughput Chemical Synthesis Tools / Steven V Ley, Ian R Baxendale, Deborah A Longbottom, Rebecca M Myers

Insulin Sensitizers: Emerging Therapeutics / Braj B Lohray, Vidya B Lohray

Criteria for Industrial Readiness of Chiral Catalysis Technology for the Synthesis of Pharmaceuticals / Raymond McCague, Ian C Lennon

Enantioselective Synthesis of Propargyl Alcohols as Multifunctional Synthons / J S Yadav, S Chandrasekhar

Carbohydrates: From Chirons to Mimics / G V M Sharma, Palakodety Radha Krishna

Meeting the Challenges of Process Development and Scale-up of Active Pharmaceutical Ingredients / Yatendra Kumar, B Vijayaraghavan

Importance of Polymorphs and Salts in the Pharmaceutical Industry / Bipin Pandey, Vidya B Lohray, Braj B Lohray

Role of Outsourcing in Drug Manufacture / Peter Pollak

Regulation-Driven Process Chemistry / Shrikant V Kulkarni

Chemical Process Scale-Up Tools: Mixing Calculations, Statistical Design of Experiments, and Automated Laboratory Reactors / Andrei A Zlota

Library Quality Metrics / Richard L Wife, Johan Tijhuis

Tying a GABA from Copenhagen to Chicago: The Chemistry of Tiagabine / Mukund S Chorghade, Mahendra N Deshpande, Richard J Pariza Building Contract Research Businesses Based on Integration of

Basic and Applied Research / Mukund S Chorghade, Mukund K Gurjar, C V Ramana, Sreenivas Punna

Principles and Practice of Clinical Drug Development / Colin Scott

Index.

Volume 1. Drug discovery [chapters 1-16]

Volume 2. Drug development [chapters 17-31].

From patent to prescription: paving the perilous path to profit / Richard J. Pariza

Medicinal chemistry in the new millennium: a glance into the future / Paul W. Erhardt

Contemporary drug discovery / Lester A. Mitscher, Apurba Dutta

Combinatorial chemistry in the drug discovery process / Ian Hughes

Parallel solution-phase synthesis / Norton P. Peet, Hwa-Ok Kim

Timing of analog research in medicinal chemistry / Ja´nos Fischer, Aniko´ Gere

Possible alternatives to high-throughput screening / Camille G. Wermuth

Proteomics and drug discovery / Susan Dana Jones, Peter G. Warren

Using drug metabolism databases during drug design and development / Paul W. Erhardt

Discovery of the antiulcer drug Tagamet / C. Robin Ganellin

Discovery of potent nonpeptide vasopressin receptor antagonists / Bruce E. Maryanoff

Discovery and development of the ultrashort-acting analgesic Remifentanil / Paul L. Feldman

Discovery and development of Nevirapine / Karl Grozinger, John Proudfoot, Karl Hargrave

Applications of nuclear imaging in drug discovery and development / John W. Babich, William C. Eckelman

Polymeric sequestrants as nonabsorbed human therapeutics / Pradeep K. Dhal, Chad C. Huval, S. Randall Holmes-Farley

Botanical immunomodulators and chemoprotectants in cancer therapy / Bhushan Patwardhan, Manish Gautam, Sham Diwanay

Bioactive molecules in medicinal plants: a perspective on their therapeutic action / S.C. Taneja, G.N. Qazi

Natural products as an inspiration for the discovery of new high-throughput chemical synthesis tools / Steven V. Ley, Ian R. Baxendale, Deborah A. Longbottom, Rebecca M. Myers

Insulin sensitizers: emerging therapeutics / Braj B. Lohray, Vidya B. Lohray

Criteria for industrial readiness of chiral catalysis technology for the synthesis of pharmaceuticals / Raymond McCague, Ian C. Lennon

Enantioselective synthesis of propargyl alcohols as multifunctional synthons / J.S. Yadav, S. Chandrasekhar Carbohydrates: from chirons to mimics / G.V.M. Sharma, Palakodety Radha Krishna

Meeting the challenges of process development and scale-up of active pharmaceutical ingredients / Yatendra Kumar, B. Vijayaraghavan

Importance of polymorphs and salts in the pharmaceutical industry / Bipin Pandey, Vidya B. Lohray, Braj B. Lohray

Role of outsourcing in drug manufacture / Peter Pollak

Regulation-driven process chemistry / Shrikant V. Kulkarni

Chemical process scale-up tools: mixing calculations, statistical design of experiments, and automated laboratory reactors / Andrei A. Zlota

Library quality metrics / Richard L. Wife, Johan Tijhuis

Tying a GABA from Copenhagen to Chicago: the chemistry of Tiagabine / Mukund S. Chorghade, Mahendra N. Deshpande, Richard J. Pariza

Building contract research businesses based on integration of basic and applied research / Mukund S. Chorghade, Mukund K. Gurjar, C.V. Ramana, Sreenivas Punna

Principles and practice of clinical drug development / Colin Scott

Über Autor(innen)

Mukund S. Chorghade, PHD, is President of Chorghade Enterprises, Inc., a firm based in Natick, Massachusetts that provides consultations to major pharmaceutical companieson collaborations with worldwide academic, government, and industrial laboratories; European technology-based companies; process reengineering; and project management of technology transfer.