Coffey / Ramzy Frozen Section Library: Gynecologic Pathology Intraoperative Consultation

1. Auflage 2011
ISBN: 978-0-387-95958-0
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 11, 240 Seiten

Reihe: Frozen Section Library

Frozen sections are performed while a patient is undergoing surgery as a basis for making an immediate diagnosis that will impact treatment decisions. Frozen section diagnosis is often a highly demanding situation for the pathologist who must render a diagnosis quickly, based on careful gross examination of specimens to select optimal areas for microscopic examination.The Frozen Section Library series will provide concise, user-friendly, site specific handbooks that are well illustrated and highlight the pitfalls, artifacts and differential diagnosis issues that arise in the hurried frozen section scenario.Donna M. Coffey, M.D., is Assistant Professor, Department of Pathology and Laboratory Medicine, The Methodist Hospital, Houston, Texas and Weill Medical College of Cornell University, New York, New York.Ibrahim Ramzy, M.D., is Professor of Pathology - Laboratory Medicine & Obstetrics-Gynecology, University of California, Irvine, California and Adjunct Professor of Pathology, Baylor College of Medicine, Houston, Texas.

Autoren/Hrsg.

Coffey, Donna M.

Ramzy, Ibrahim

Inhaltsverzeichnis

1;Frozen Section Library: Gynecologic Pathology Intraoperative Consultation;3
1.1;Foreword;7
1.2;Preface;9
1.3;Contents;11
1.4;Chapter 1: General Principles;13
1.4.1;Recommended Reading;15
1.5;Chapter 2: Vulva;17
1.5.1;Vulvar Biopsies and Other Limited Procedures;17
1.5.1.1;Clinical Background and Specimen Handling;17
1.5.1.2;Interpretation and Limitations;18
1.5.2;Vulvectomy for Squamous Cell Cancer;19
1.5.2.1;Clinical Background and Specimen Types;19
1.5.2.2;Specimen Handling;20
1.5.2.3;Interpretation and Differential Diagnostic Considerations;21
1.5.2.3.1;Vulvar Intraepithelial Neoplasia;23
1.5.2.3.2;Invasive Squamous Cell Carcinomas;25
1.5.2.3.3;Verrucous Carcinoma;29
1.5.2.4;Differential Diagnosis of Verrucous Lesions;30
1.5.2.4.1;Key Histologic Features of Verrucous Carcinoma;30
1.5.2.4.2;Key Histologic Features of Warty (Condylomatous) Carcinoma;31
1.5.2.4.3;Key Features of Condyloma Acuminatum;31
1.5.3;Lymph Node Dissection in Vulvar Cancer;32
1.5.4;Vulvectomy for Other Malignancies;32
1.5.4.1;Malignant Melanoma;32
1.5.4.1.1;Differential Diagnostic Considerations;36
1.5.4.2;Extramammary Paget Disease;36
1.5.4.2.1;Differential Diagnostic Considerations;37
1.5.4.3;Primary Adenocarcinoma;38
1.5.4.3.1;Differential Diagnostic Considerations;39
1.5.4.4;Basal Cell Carcinoma;41
1.5.4.5;Metastatic Neoplasms;41
1.5.5;Recommended Reading;42
1.6;Chapter 3: Vagina;44
1.6.1;Vaginectomy for Squamous Cell Neoplasms;44
1.6.1.1;Clinical Background;44
1.6.1.2;Specimen Handling;45
1.6.1.3;Interpretation;47
1.6.1.4;Differential Diagnostic Considerations;53
1.6.2;Vaginectomy for Adenocarcinoma;55
1.6.2.1;Clinical Background and Specimen Handling;55
1.6.2.2;Interpretation;56
1.6.2.3;Differential Diagnostic Considerations;58
1.6.3;Vaginectomy for Sarcomas and Other Spindle Cell Lesions;62
1.6.3.1;Clinical Background;62
1.6.3.2;Interpretation and Differential Diagnostic Considerations;63
1.6.4;Recommended Reading;68
1.7;Chapter 4: Uterine Cervix;70
1.7.1;Cervical Punch Biopsy;70
1.7.2;Loop Electrosurgical Excision Procedure;71
1.7.3;Cervical Cone Biopsy;72
1.7.3.1;Clinical Background;72
1.7.3.2;Specimen Handling;73
1.7.3.3;Interpretation;73
1.7.3.4;Limitations of Conization;73
1.7.3.5;Impact of Conization on Management;80
1.7.4;Radical Trachelectomy;81
1.7.4.1;Clinical Background;81
1.7.4.2;Specimen Handling;82
1.7.4.3;Assessment of Endocervical Margin in Trachelectomy;82
1.7.4.4;Alternative Techniques of Handling Trachelectomy;82
1.7.5;Tumors of the Cervix: Evaluation and Differential Diagnosis;84
1.7.6;Squamous Cell Carcinoma;84
1.7.6.1;Cervical Intraepithelial Neoplasms;85
1.7.6.2;Microinvasive Carcinomas;85
1.7.6.2.1;Key Features of Microinvasive (Superficially Invasive) Squamous Carcinoma;88
1.7.6.3;Invasive Squamous Cell Carcinoma;88
1.7.6.4;Differential Diagnostic Considerations;91
1.7.7;Adenocarcinoma;93
1.7.7.1;Glandular Intraepithelial Neoplasia;94
1.7.7.1.1;Key Histologic Features of AIS;95
1.7.7.2;Invasive Adenocarcinomas;95
1.7.7.3;Mucinous Adenocarcinoma;96
1.7.7.3.1;Key Histologic Features of Mucinous Adenocarcinoma;100
1.7.7.4;Endometrioid Adenocarcinoma;100
1.7.7.5;Minimal Deviation Adenocarcinoma;102
1.7.7.6;Differential Diagnostic Considerations;102
1.7.8;Neuroendocrine Carcinomas;104
1.7.9;Uncommon Neoplasms;108
1.7.10;References;110
1.8;Chapter 5: Uterine Body;113
1.8.1;Reasons for Intraoperative Consultation;113
1.8.2;Uterine Corpus Specimens;113
1.8.3;Endometrial Curettage and Endometrial Biopsy;114
1.8.3.1;Clinical Background;114
1.8.3.2;Specimen Handling;114
1.8.3.3;Interpretation and Differential Diagnostic Considerations;115
1.8.4;Hysterectomy for Benign Disease;115
1.8.5;Myomectomy;116
1.8.5.1;Clinical Background;116
1.8.5.2;Specimen Handling and Interpretation;116
1.8.6;Endometrial Polypectomy;117
1.8.6.1;Clinical Background and Specimen Handling;117
1.8.6.2;Interpretation and Differential Diagnostic Considerations;117
1.8.7;Hysterectomy for Cervical Cancer;120
1.8.7.1;Clinical Background and Types of Hysterectomy;120
1.8.7.2;Specimen Handling;122
1.8.7.3;Interpretation;122
1.8.8;Pelvic Lymph-Node Resection;122
1.8.8.1;Clinical Background;122
1.8.8.2;Specimen Handling;123
1.8.8.3;Interpretation and Differential Diagnostic Considerations;124
1.8.9;Hysterectomy for Endometrial Hyperplasia;125
1.8.9.1;Clinical Background;125
1.8.9.2;Specimen Handling;125
1.8.9.3;Interpretation;125
1.8.9.4;Differential Diagnostic Considerations;126
1.8.10;Hysterectomy for Endometrial Carcinoma;129
1.8.10.1;Clinical Background;129
1.8.10.2;Specimen Handling;130
1.8.10.3;Interpretation and Differential Diagnostic Considerations;132
1.8.10.3.1;Endometrioid Adenocarcinoma;133
1.8.10.3.2;Variants of Endometrioid Adenocarcinoma;135
1.8.10.3.3;Serous Papillary Carcinoma;137
1.8.10.3.3.1;Key Histologic Features of Serous Carcinoma;140
1.8.10.3.3.2;Key Histologic Features of Villoglandular Adenocarcinoma;140
1.8.10.3.4;Clear Cell Carcinoma;140
1.8.10.3.4.1;Key Histologic Features of Clear Cell Carcinoma;141
1.8.10.3.4.2;Key Histologic Features of Secretory Carcinoma;141
1.8.11;Hysterectomy for Sarcomas;142
1.8.11.1;Clinical Background;142
1.8.11.2;Specimen Handling;142
1.8.11.3;Interpretation and Differential Diagnostic Considerations;143
1.8.11.3.1;Leiomyosarcoma and Other Smooth Muscle Neoplasms;143
1.8.11.3.2;Epithelioid Smooth Muscle Tumor;148
1.8.11.3.3;Endometrial Stromal Sarcoma;150
1.8.11.4;Carcinosarcoma (Malignant Mixed Müllerian Tumor);153
1.8.11.5;Adenosarcoma;160
1.8.12;Recommended Reading;161
1.9;Chapter 6: Ovary and Fallopian Tube;163
1.9.1;General Considerations;164
1.9.2;Ovarian and Tubal Specimens;166
1.9.2.1;Staging;166
1.9.3;Oophorectomy and Salpingooophorectomy;167
1.9.3.1;Specimen Handling;167
1.9.4;Cystectomy;168
1.9.4.1;Clinical Background;168
1.9.4.2;Specimen Handling and Interpretation;169
1.9.5;Ovarian Biopsy;169
1.9.6;Omental and Peritoneal Biopsies;170
1.9.7;Lymph Node Sampling;170
1.9.8;Pelvic, Peritoneal and Gutter Lavages;172
1.9.9;Interpretation and Differential Diagnosis in Adnexal Lesions;172
1.9.10;Non-neoplastic Lesions;173
1.9.11;Surface Epithelial Tumors;176
1.9.11.1;Serous Neoplasms;179
1.9.11.1.1;Key Features of Benign Serous Tumors (Figs.  6.11 – 6.14);180
1.9.11.1.2;Key Features of Serous Borderline Tumors (Figs.  6.15 and 6.16);185
1.9.11.1.3;Key Features of Serous Adenocarcinoma (Figs.  6.17 and 6.18);187
1.9.11.2;Serous Carcinoma of the Peritoneum;187
1.9.11.2.1;Key Features of Serous Carcinoma of the Peritoneum;187
1.9.11.3;Peritoneal Implants;187
1.9.11.3.1;Key Features of Noninvasive Implants;187
1.9.11.3.2;Key Features of Invasive Implants;188
1.9.11.4;Mucinous Neoplasms;188
1.9.11.4.1;Key Features of Primary Benign Mucinous Tumors;188
1.9.11.4.2;Key Features of Mucinous Borderline Tumors;193
1.9.11.4.3;Key Features of Primary Mucinous Adenocarcinoma;194
1.9.11.5;Peritoneal Adenomucinosis (Pseudomyxoma Peritoneii);195
1.9.11.6;Endometrioid Tumors;195
1.9.11.6.1;Key Features of Benign Endometrioid Tumors;197
1.9.11.6.2;Key Features of Borderline Endometrioid Tumors;198
1.9.11.6.3;Key Features of Endometrioid Adenocarcinomas;198
1.9.11.7;Clear Cell Neoplasms;198
1.9.11.7.1;Key Features of Benign and Borderline Clear Cell Tumors;199
1.9.11.7.2;Key Features of Clear Cell Carcinoma;199
1.9.11.8;Transitional Cell (Brenner) Tumors;200
1.9.11.9;Other Surface Epithelial Neoplasms;200
1.9.12;Sex Cord and Stromal Tumors;201
1.9.12.1;Granulosa Cell Tumors;204
1.9.12.1.1;Key Features of Adult Granulosa Cell Tumors;206
1.9.12.1.2;Key Features of Juvenile Granulosa Cell Tumors;206
1.9.12.2;Theca Cell Tumor and Fibroma;209
1.9.12.2.1;Key Features of Theca Cell Tumors;212
1.9.12.3;Sertoli–Leydig Cell Tumor (Androblastoma);213
1.9.12.3.1;Key Features of Sertoli–Leydig Tumors;214
1.9.12.4;Other Sex Cord Stromal Neoplasms;214
1.9.13;Germ Cell Neoplasms;218
1.9.13.1;Mature Cystic Teratoma;218
1.9.13.1.1;Key Features of Mature Cystic Teratoma;219
1.9.13.2;Immature Teratoma;220
1.9.13.3;Mature Solid Teratoma;221
1.9.13.4;Monomorphic Teratomas;221
1.9.13.5;Dysgerminoma;224
1.9.13.5.1;Key Features of Dysgerminoma;226
1.9.13.6;Other Malignant Germ Cell Tumors;227
1.9.14;Metastatic Tumors;229
1.9.14.1;Key Features that Favor Metastases over Primary Ovarian Tumors;230
1.9.14.2;Krukenberg Tumor;235
1.9.15;Fallopian Tube Tumors;236
1.9.16;Recommended Reading;237
1.10;Chapter 7: Concluding Remarks;239
1.11;Index;240