GABAB Receptor

2016
ISBN: 978-3-319-83428-3
Verlag: Springer

Buch, Englisch, 385 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 616 g

Reihe: The Receptors

An up-to-date comprehensive overview of the GABA B receptor system with a particular focus on the most recent therapeutic applications and potential. This receptor system has recently been implicated in several diseases and disorders including gastroesophageal reflux disease, epilepsy, mood disorders, depression, and alcohol and substance use disorder. The authors, leading researchers in the field, explore a number of approaches, including medicinal chemistry, molecular biology, physiology, and preclinical and clinical pharmacology. This overview provides a translational perspective on the potential of the GABA B receptor pharmacology.

Zielgruppe

Research

Autoren/Hrsg.

Colombo, Giancarlo

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft

Inhaltsverzeichnis

1. Historical Perspectives on the GABA Receptor.- Section 1. Chemistry.- 2. Chemistry of GABA Receptor Ligands: Focus on Agonists and Antagonists.- 3. Chemistry of GABA Receptor Ligands: Focus on Positive Allosteric Modulators.- Section 2. Molecular Biology, Biochemistry, & Physiology.- 4. Molecular Structure and Trafficking of the GABA Receptor.- 5. Distribution and Localization of the GABA Receptor.- 6. Activation Mechanism and Allosteric Properties of the GABA Receptor.- 7. Modulation of Neurotransmission by the GABA Receptor.- 8. GABA Receptor Functions In The Mesolimbic Dopamine System.- Section 3. Pharmacology.- 9. Drug Discrimination Studies for Investigations on the Mechanisms of Action of GABA Receptor Ligands.- 10. Targeting the GABA Receptor for the Treatment of Epilepsy.- 11. Targeting the GABA Receptor for the Treatment of Pain.- 12. Targeting the GABA Receptor for the Treatment of Psychiatric Disorders.- 13. Targeting the GABA Receptor for the Treatment of Fragile X Syndrome and Autism Spectrum Disorders.- 14. Targeting the GABA Receptor for the Treatment of Substance Use Disorder.- 15. Targeting the GABA Receptor for the Treatment of Alcohol Use Disorder.- 16. Targeting GABA Receptors for the Treatment of Gastroesophageal Reflux Disease and Chronic Cough.- 17. Baclofen: Therapeutic Use and Potential of the Prototypic GABA Receptor Agonist.- 18. Allosteric Modulators: The New Generation of GABA Receptor Ligands.- 19. GABA Receptor Antagonists as Cognition Enhancers.

Über Autor(innen)

Giancarlo Colombo is a researcher at the Neuroscience Institute, Section of Cagliari, National Research Council of Italy. He has previously worked at the Laboratory of Physiologic and Pharmacologic Studies, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA, and the Department of Physiology and Pharmacology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC, USA.

His research interest is primarily on neurobiology and pharmacology of alcohol use disorder, with focus on the role of GABAB receptor in the control of multiple alcohol-related behaviors and the development of GABAB receptor ligands as possible pharmacotherapies for alcohol use disorder.

He has published approximately 200 papers in peer-reviewed journals and about 20 book chapters. He serves on the editorial board of the journals Alcohol and Alcohol and Alcoholism.