Dalgleish / Haefner The Link Between Inflammation and Cancer

Wounds that do not heal
1. Auflage 2006
ISBN: 978-0-387-26283-3
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 130, 254 Seiten

Reihe: Cancer Treatment and Research

A link between inflammation and cancer has been established many years ago, yet it is only recently that the potential significance of this connection has become apparent. Although several examples of chronic inflammatory conditions, often induced by persistent irritation and/or infection, developing into cancer have been known for some time, there has been a notable resistance to contemplate the possibility that this association may apply in a causative way to other cancers. Examples for such progression from chronic inflammation to cancer are colon carcinoma developing with increased frequency in patients with ulcerative colitis, and the increased incidence of bladder cancer in patients suffering from chronic Schistosoma infection. Inflammation and cancer have been recognized to be linked in another context for many years, i.e., with regards to pathologies resembling chronic lacerations or 'wounds that do not heal.' More recently, the immunology of wound healing has given us clues as to the mechanistic link between inflammation and cancer, in as much as wounds and chronic inflammation turn off local cell-mediated immune responses and switch on growth factor release as well the growth of new blood vessels - angiogenesis. Both of these are features of most types of tumours, which suggest that tumours may require an immunologically shielded milieu and a growth factor-rich environment.

Autoren/Hrsg.

Haefner, Burkhard

Dalgleish, Angus G.

Inhaltsverzeichnis

1;CONTENTS;5
2;FOREWORD;7
3;CONTRIBUTORS;10
4;Chapter 1 INFLAMMATION AND CANCER: The role of the immune response and angiogenesis;12
5;Chapter 2 CHRONIC INFLAMMATION AND PATHOGENESIS OF GI AND PANCREATIC CANCERS;50
6;Chapter 3 CYTOKINES, NF-KB, MICROENVIRONMENT, INTESTINAL INFLAMMATION AND CANCER;77
7;Chapter 4 REGULATION OF NF-KB TRANSCRIPTIONAL ACTIVITY;98
8;Chapter 5 THE ROLE OF IMMUNE CELLS IN THE TUMOR MICROENVIRONMENT;112
9;Chapter 6 TUMOR- MICROENVIRONMENT INTERACTIONS: The Selectin-Selectin Ligand Axis in Tumor-Endothelium Cross Talk;134
10;Chapter 7 CD95L/ FASL AND TRAIL IN TUMOUR SURVEILLANCE AND CANCER THERAPY;150
11;Chapter 8 INFECTION & NEOPLASTIC GROWTH 101;175
12;Chapter 9 CYTOKINES AS MEDIATORS AND TARGETS FOR CANCER CACHEXIA;206
13;Chapter 10 TARGETING NF-KB IN ANTICANCER ADJUNCTIVE CHEMOTHERAPY;225
14;Index;252