Dhawan / Bajpayee | Genotoxicity Assessment | Buch | sack.de

Dhawan / Bajpayee Genotoxicity Assessment



Methods and Protocols

2. Auflage 2019, Band: 2031, 378 Seiten, Gebunden, HC runder Rücken kaschiert, Format (B × H): 189 mm x 253 mm, Gewicht: 851 g Reihe: Methods in Molecular Biology
ISBN: 978-1-4939-9645-2
Verlag: Springer, Berlin


Dhawan / Bajpayee Genotoxicity Assessment

This current edition explores new tests for genotoxicity testing, along with other well-known techniques. This will further help in our understanding of the genotoxic effects of chemicals. The book has different sections dealing with various assays for gene mutation, chromosomal abnormalities, primary DNA damage, etc. It also delves into plant models, animals and their alternates, as well as in silico approaches for genetic toxicology. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, tips on troubleshooting and avoiding known pitfalls.
Authoritative and up-to-date, Genotoxicity Assessment: Methods and Protocols, Second Edition serves as a highly useful and ready resource for research students and scientists working in regulatory toxicology as well as biomedical, biochemical, and pharmaceutical sciences.

Zielgruppe


Professional/practitioner

Weitere Infos & Material


Part I: Gene Mutation Assays 1. In Vitro Mouse Lymphoma Cell (L5178Y Tk+/- -3.7.2.C) Forward Mutation Assay            Melissa R. Schisler, Martha M. Moore, and B. Bhaskar Gollapudi 2. Erythrocyte-Based Pig-a Gene Mutation Assay            Jeffrey C. Bemis, Nikki E. Hall, and Stephen D. Dertinger 3. Detection of In Vivo Mutation in the Hprt and Pig-a Genes of Rat Lymphocytes            Vasily N. Dobrovolsky, Joseph G. Shaddock, Roberta A. Mittelstaedt, Daishiro Miura, and Robert H. Heflich Part II: Assays for Chromosomal Abnormalities 4. In Vitro Cytogenetic Assays: Chromosomal Aberrations and Micronucleus Tests            Pasquale Mosesso and Serena Cinelli 5. Dicentric Chromosome Assay (DCA) and Cytokinesis-Block Micronucleus (CBMN) Assay in the Field of Biological Dosimetry            Antonella Testa, Valentina Palma, and Clarice Patrono 6. Chromosomal Aberration Test in Human Lymphocytes            Christian Johannes and Guenter Obe 7. In Vivo Micronucleus Assay in Mouse Bone Marrow            Abhishek Kumar Jain and Alok Kumar Pandey 8. Micronucleus Cytome Assays in Human Lymphocytes and Buccal Cells            Claudia Bolognesi and Michael Fenech 9. Micronucleus Analysis by Flow Cytometry            Azeddine Elhajouji and Pascal Stadelmann 10. Hen's Egg Test for Micronucleus Induction (HET-MN)            Kerstin Reisinger, Eva Dony, Thorsten Wolf, and Katrin Maul 11. Comparative Genomic Hybridization (CGH) in Genotoxicology            Adi Baumgartner, Veronika Hartleb, and Jim D. Taylor Part III: Tests for Primary DNA Damage 12. The Comet Assay: Assessment of In Vitro and In Vivo DNA Damage            Mahima Bajpayee, Ashutosh Kumar, and Alok Dhawan 13. The Comet Assay in Human Biomonitoring            Diana Anderson and Julian Laubenthal 14. The Comet Assay in Marine Animals            Patrizia Guidi, Brett P. Lyons, and Giada Frenzilli 15. Multicolour Laser Scanning Confocal Immunofluorescence Microscopy of DNA Damage Response Biomarkers            Julian Laubenthal, Michal R. Gdula, Alok Dhawan, and Diana Anderson 16. Detection of DNA Double Strand Breaks Using Pulse Field Gel Electrophoresis            Vyom Sharma and Vishwa Mohan 17. Detection of UV-Induced Thymine Dimers            Vipin Kumar Yadav, Poorwa Awasthi, and Amit Kumar Part IV: Assays in Plants and Alternate Animal Models 18. Micronucleus Assay with Tetrad Cells of Tradescantia            Miroslav Misík, Clemens Pichler, Bernhard Rainer, Armen Nersesyan, Katarina Misíková, and Siegfried Knasmueller 19. The Wing-Spot and the Comet Tests as Useful Assays for Detecting Genotoxicity in Drosophila            Ricard Marcos and Erico R. Carmona Part V: In Silico Testing for Genetic Toxicology 20. In Silico Approaches in Predictive Genetic Toxicology            Meetali Sinha, Alok Dhawan, and Ramkrishnan Parthasarathi


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