Buch, Englisch, 544 Seiten, Format (B × H): 191 mm x 244 mm, Gewicht: 1043 g
ISBN: 978-1-119-97810-7
Verlag: Wiley
Praised forits clarity of presentation and accessibility, Introduction to Modern Virology has been a successful student text for over 30 years. It provides a broad introduction to virology, which includes the nature of viruses, the interaction of viruses with their hosts and the consequences of those interactions that lead to the diseases we see. This new edition contains a number of important changes and innovations including:
- The consideration of immunology now covers two chapters, one on innate immunity and the other on adaptive immunity, reflecting the explosion in knowledge of viral interactions with these systems.
- The coverage of vaccines and antivirals has been expanded and separated into two new chapters to reflect the importance of these approaches to prevention and treatment.
- Virus infections in humans are considered in more detail with new chapters on viral hepatitis, influenza, vector-borne diseases, and exotic and emerging viral infections, complementing an updated chapter on HIV.
- The final section includes three new chapters on the broader aspects of the influence of viruses on our lives, focussing on the economic impact of virus infections, the ways we can use viruses in clinical and other spheres, and the impact that viruses have on the planet and almost every aspect of our lives.
A good basic understanding of viruses is important for generalists and specialists alike. The aim of this book is to make such understanding as accessible as possible, allowing students across the biosciences spectrum to improve their knowledge of these fascinating entities.
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Preface xvii
About the companion website xix
Part I The Nature of Viruses 1
Chapter 1 Towards a definition of a virus 3
1.1 Discovery of viruses 4
1.2 Multiplication of viruses 5
1.3 The virus multiplication cycle 6
1.4 Viruses can be defined in chemical terms 7
1.5 Multiplication of bacterial and animal viruses is fundamentally similar 10
1.6 Viruses can be manipulated genetically 11
1.7 Properties of viruses 11
1.8 Origin of viruses 12
Key points 12
Further reading 12
Chapter 2 The structure of virus particles 13
2.1 Virus particles are constructed from subunits 13
2.2 The structure of filamentous viruses and nucleoproteins 14
2.3 The structure is of isometric virus particles 15
2.4 Enveloped (membrane-bound) virus particles 24
2.5 Virus particles with head-tail morphology 27
2.6 Frequency of occurrence of different virus particle morphologies 28
2.7 Principles of disassemply: virus particles are metastable 28
Key points 29
Further reading 29
Chapter 3 Classification of viruses 30
3.1 Classification on the basis of disease 30
3.2 Classification on the basis of host organism 31
3.3 Classification on the basis of virus particle morphology 31
3.4 Classification on the basis of viral nucleic acids 32
3.5 Classification on the basis of taxonomy 34
3.6 Satellites, viroids and prions 35
Key points 37
Further reading 38
Chapter 4 The evolution of viruses 39
4.1 Mechanisms of virus evolution 40
4.2 The potential for rapid evolution: mutation and quasispecies 40
4.3 Rapid evolution: recombination 43
4.4 Rapid evolution: reassortment 43
4.5 Evolution to find a host, and subsequent co-evolution with the host 46
Key points 51
Questions 51
Further reading 51
Chapter 5 Techniques for studying viruses 52
5.1 Culturing wild virus isolates 52
5.2 Enumeration of viruses 54
5.3 Measuring infectious virus titres 55
5.4 Measuring physical virus titres 57
5.5 Detecting virus in a sample 58
5.6 Understanding virus replication cycles 62
5.7 Viral genetics and reverse genetics 63
5.8 Systems-level virology 63
Key points 65
Questions 65
Further reading 65
Part II Virus Growth in Cells 67
Chapter 6 The process of infection: I. Virus attachment and entry into cells 69
6.1 Infection of animal cells: the nature and importance of receptors 69
6.2 Infection of animal cells: enveloped viruses 73
6.3 Infection of animal cells: non-enveloped viruses 78
6.4 Infection of plant cells 80
6.5 Infection of bacteria 81
6.6 Infection of cells: post-entry events 82
6.7 Virus entry: cell culture and the whole organism 84
Key points 84
Questions 84
Further reading 85
Chapter 7 The process of infection: IIA. The replication of viral DNA 86
7.1 The universal mechanism of DNA synthesis 87
7.2 Replication of circular double-stranded DNA genomes 90
7.3 Replication of linear double-stranded DNA genomes that can form circles 93
7.4 Replication of linear double-stranded DNA genomes that do not circularize 96
7.5 Replication of single-stranded circular DNA genomes 100
7.6 Replication of single-stranded linear DNA genomes 100
7.7 Dependency versus autonomy among DNA viruses 103
Key points 103
Questions 103
Further reading 103
Chapter 8 The process of infection: IIB. Genome replication in RNA viruses 105
8.1 Nature and diversity of RNA virus genomes 106
8.2 Regulatory elements for RNA virus genome synthesis 106
8.3 Synthesis of the RNA genome of Baltimore class 3 viruses 111
8.4 Synthesis of the RNA genome of Baltimore class 4 viruses 111
8.5 Synthesis of the RNA genome of Baltimore class 5 viruses 115
8.6 Synthesis of the RNA genome of viroids and hepatitis delta virus 118
Key points 119
Questions 119
Further reading 119
Chapter 9 The process of infection: IIC. The replication of RNA viruses with a DNA intermediate and vice versa 121
9.1 The retrovirus replication cycle 122
9.2 Discovery of reverse transcription 122
9.3 Retroviral reverse transcriptase 123
9.4 Mechanism of retroviral reverse transcription 125
9.5 Integration of retroviral DNA into cell DNA 128
9.6 Production of retrovirus progeny genomes 130
9.7 Spumaviruses: retrovirus with unusual features 131
9.8 The hepadnavirus replication cycle 131
9.9 Mechanism of hepadnavirus reverse transcription 131
9.10 Comparing reverse transcribing viruses 134
Key points 134
Questions 134
Further reading 135
Chapter 10 The process of infection: IIIA. Gene expression in DNA viruses and reverse-transcribing viruses 136
10.1 The DNA viruses and retroviruses: Baltimore classes 1, 2, 6 and 7 137
10.2 Polyomaviruses 138
10.3 Papillomaviruses 142
10.4 Adenoviruses 144
10.5 Herpesviruses 147
10.6 Poxviruses 149
10.7 Parvoviruses 149
10.8 Retroviruses 150
10.9 Hepadnaviruses 153
10.10 DNA bacteriophages 154
Key points 154
Questions 155
Further reading 155
Chapter 11 The process of infection: IIIB. Gene expression and its regulation in RNA viruses 156
11.1 The RNA viruses: Baltimore classes 3, 4 and 5 157
11.2 Reoviruses 158
11.3 Picornaviruses 163
11.4 Alphaviruses 164
11.5 Coronaviruses 166
11.6 Negative sense RNA viruses with segmented genomes 169
11.7 Orthomyxoviruses 169
11.8 Arenaviruses 173
11.9 Negative sense RNA viruses with non-segmented, single stranded genomes: rhabdoviruses and paramyxoviruses 174
Key points 177
Questions 178
Further reading 178
Chapter 12 The process of infection: IV. The assembly of viruses 179
12.1 Self-assembly from mature virion components 180
12.2 Assembly of viruses with a helical structure 180
12.3 Assembly of viruses with an isometric structure 184
12.4 Assembly of complex viruses 187
12.5 Sequence-dependent and -independent packaging of virus DNA in virus particles 189
12.6 The assembly of enveloped viruses 190
12.7 Segmented virus genomes: the acquisition of multiple nucleic acid molecules 194
12.8 Maturation of virus particles 195
Key points 196
Questions 197
Further reading 197
Part III Virus Interactions with the Whole Organism 199
Chapter 13 Innate and intrinsic immunity 201
13.1 Innate immune responses in vertebrates – discovery of interferon 202
13.2 Induction of type 1 interferon responses 203
13.3 Virus countermeasures to innate immunity 207
13.4 TRIM proteins and immunity 209
13.5 Intrinsic resistance to viruses in vertebrates 210
13.6 Innate and intrinsic immunity and the outcome of infection 212
13.7 RNAi is an important antiviral mechanism in invertebrates and plants 212
13.8 Detecting and signalling infection in invertebrates and plants 214
13.9 Virus resistance mechanisms in bacteria and archaea 215
Key points 216
Questions 217
References 217
Chapter 14 The adaptive immune response 218
14.1 General features of the adaptive immune system 219
14.2 Cell-mediated immunity 221
14.3 Antibody-mediated humoral immunity 226
14.4 Virus evasion of adaptive immunity 232
14.5 Age and adaptive immunity 233
14.6 Interaction between the innate and adaptive immune systems 233
Key points 234
Questions 236
Further reading 236
Chapter 15 Interactions between animal virus
