Buch, Englisch, 199 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 3226 g
Buch, Englisch, 199 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 3226 g
Reihe: Resistance to Targeted Anti-Cancer Therapeutics
ISBN: 978-3-319-82528-1
Verlag: Springer
This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy.The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.
Zielgruppe
Research
Autoren/Hrsg.
Fachgebiete
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
Weitere Infos & Material
Introduction.- Basic rules of T cell migration.- Regulation of anti-tumor T cell migration and function: contribution of real-time imaging.- Vascular normalization, T cell trafficking and anti-tumor immunity.- Disruption of anti-tumor T cell responses by cancer-associated fibroblasts.- Cancer-associated Tertiary Lymphoid Structures, from basic knowledge toward therapeutic target in clinic.- Homing Improvement: Boosting T Cell Trafficking for Cancer Immunotherapy.- Chemokines and T cell trafficking into tumors. Strategies to enhance recruitment of T cells into tumors.- Strategies to enhance migration and persistence of chimeric antigen receptor (CAR)-T cells into tumors.