Buch, Englisch, 536 Seiten, Format (B × H): 235 mm x 287 mm, Gewicht: 1463 g
Buch, Englisch, 536 Seiten, Format (B × H): 235 mm x 287 mm, Gewicht: 1463 g
ISBN: 978-1-55581-603-2
Verlag: ASM Press
A springboard for developing new approaches to understanding, preventing, and treating picornaviral diseases.
Examines the most current breakthroughs as well as the challenges that lie ahead in picornavirus research; encapsulates current knowledge of the molecular biology, evolution, and pathogenesis of this large family of viruses; and, examines the diseases that these viruses cause and the latest vaccines and antiviral drugs to prevent and control those diseases.
Explores the structural and mechanistic bases of picornavirus replication, highlighting new insights about the host cell interactions needed for virus growth; and, illustrates how the regular occurrence of mutations, typical of viruses with RNA as genetic material, generates the quasispecies dynamics that underlie viral fitness.
Focuses on picornaviruses that cause disease, examining pathogenicity and innate and acquired immune responses against infection as well as the latest vaccine and antiviral drug strategies.
This title is published by the American Society of Microbiology Press and distributed by Taylor and Francis in rest of world territories.
Autoren/Hrsg.
Weitere Infos & Material
Table of Contents
I. Introduction to Picornavirus Biology
1. Genome Organization and Encoded Proteins, Ann Palmenberg, David Neubauer, and Tim Skern
2. Overview of Taxonomy, Nick J. Knowles, Tapani Hovi, Andrew M. Q. King, and Glyn Stanway
3. The Making of a Picornavirus Genome, Eckard Wimmer and Aniko V. Paul
II. Virion Structure and Cell Entry and Assembly
4. Virion Structure, Elizabeth E. Fry and David I. Stuart
5. Receptors, Jeffrey M. Bergelson
6. Cell Entry: a Biochemical and Structural Perspective, Hazel Levy, Mihnea Bostina, David J. Filman, and James M. Hogle
III. Genome Replication and Translation
7. Genome Replication I: the Players, Janet M. Rozovics and Bert L. Semler
8. Genome Replication II: the Process, Karla Kirkegaard and Bert L. Semler
9. Translation and Protein Processing, Encarna Martínez-Salas and Martin D. Ryan
IV. Alterations of Host Cell Function
10. Interference with Cellular Gene Expression, Jonathan D. Dougherty, Nogi Park, Kurt E. Gustin, and Richard E. Lloyd
11. Remodeling Cellular Membranes, Frank van Kuppeveld, George Belov, and Ellie Ehrenfeld
V. Evolution and Mechanisms
12. Mutation, Quasispecies, and Lethal Mutagenesis, Esteban Domingo, Celia Perales, Rubén Agudo, Armando Arias, Cristina Escarmís, Cristina Ferrer-Orta, and Nuria Verdaguer
13. Biological Implications of Picornavirus Fidelity Mutants, Marco Vignuzzi and Raul Andino
14. Recombination in the Evolution of Picornaviruses, Peter Simmonds
15. Picornaviruses as a Model for Studying the Nature of RNA Recombination, Vadim I. Agol
16. Origin and Evolution of the Picornaviridae Proteome, Alexander E. Gorbalenya and Chris Lauber
17. Codon Biases and Viral Fitness, Albert Bosch, Steffen Mueller, and Rosa M. Pintó
VI. Immune Response and Persistence
18. Innate Immune Responses, Vincent R. Racaniello
19. Adaptive Immune Responses, Christopher C. Kemball, Robert S. Fujinami, and J. Lindsay Whitton
20. Persistent Infections, Florence Colbère-Garapin and Howard L. Lipton
VII. Pathogenesis of Disease
21. Poliomyelitis, Satoshi Koike and Akio Nomoto
22. Group B Coxsackievirus Diseases, Steven Tracy and Nora M. Chapman
23. Rhinovirus and Respiratory Disease, Marc B. Hershenson
24. Hepatitis A Virus, Zongdi Feng and Stanley M. Lemon
25. Foot-and-Mouth Disease, Marvin J. Grubman, Luis L. Rodriguez, and Teresa de los Santos
26. Theiler’s Virus Central Nervous System Infection, Thomas Michiels and Raymond P. Roos
VIII. Disease Prevention and Treatment
27. Vaccine Strategies, David J. Rowlands and Philip D. Minor
28. The Poliovirus Eradication Initiative, Konstantin Chumakov and Olen Kew
29. Antiviral Drugs, Armando M. De Palma and Johan Neyts
