The Zebrafish in Biomedical Research

Biology, Husbandry, Diseases, and Research Applications
Erscheinungsjahr 2019
ISBN: 978-0-12-812431-4
Verlag: Elsevier Science

Buch, Englisch, 718 Seiten, Format (B × H): 219 mm x 284 mm, Gewicht: 2124 g

The Zebrafish in Biomedical Research: Biology, Husbandry, Diseases, and Research Applications is a comprehensive work that fulfills a critical need for a thorough compilation of information on this species. The text provides significant updates for working vivarium professionals maintaining zebrafish colonies, veterinarians responsible for their care and well-being, zoologists and ethologists studying the species, and investigators using the species to gain critical insights into human physiology and disease. As the zebrafish has become an important model organism for the study of vertebrate development and disease, organ function, behavior, toxicology, cancer, and drug discovery, this book presents an important resource for future research.

Zielgruppe

<p>vivarium professionals maintaining zebrafish colonies, veterinarians responsible for their care and well-being, zoologists and ethologists studying the species, and investigators/researchers using them to gain critical insights into human physiology and disease. </p>

Autoren/Hrsg.

Cartner, Samuel

Eisen, Judith S

Farmer, Susan F

Guillemin, Karen J

Kent, Michael L

Sanders, George E

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien
• Naturwissenschaften Biowissenschaften Tierkunde / Zoologie Wirbeltiere (Vertebrata) Fische (Ichthyologie)

Inhaltsverzeichnis

I. Introduction

1. History of Zebrafish Research

2. Taxonomy/Phylogeny

3. Zebrafish Genetics

4. Geographic Range and Natural Distribution

5. Behavior of Wild Populations

II. Biology

Appearance, Development, Anatomy, Physiology

6. Zebrafish in Biomedical Research: Head and Body: Anatomy

7. Establishing the Body Plan: The First 24 Hours of Zebrafish Development

Organ Systems: Development, Anatomy, Physiology

8. Zebrafish Integumentary System

9. Zebrafish Pigmentation

10. Respiratory System

11. Skeletal System Morphophysiology

12. Zebrafish Myology

13. It Takes Guts: Development of the Embryonic and Juvenile Zebrafish Digestive System

14. The Zebrafish Cardiovascular System

15. Development of the Zebrafish Pronephric and Mesonephric Kidneys

16. Reproductive System

17. Endocrine Systems

18. Nervous Systems

19. Immunology

20. Physiology: Hematology and Clinical Chemistry, Gas Exchange, and Regulatory Osmolality

Tissues and Organs Associated with Special Senses

21. Zebrafish in Biomedical Research: The Retina and Vision

22. The Mechanosensory Lateral Line System

23. Inner Ear and Hearing

Husbandry

24. Introduction to Zebrafish Husbandry

25. Aquatic Facility Design Considerations: Incorporating Aquatics into an Animal Facility

26. Aquatic Housing

27. Cleaning and Disinfection of Life Systems

28. Zebrafish Aquatic Systems: Preventative Maintenance and Troubleshooting

29. Water Quality for Zebrafish Cultura

30. Recirculating Aquaculture Systems (RAS) for Zebrafish Culture

31. Zebrafish Breeding and Colony Management

32. Zebrafish Larviculture

33. Zebrafish Nutrition--Moving Forward

34. Anesthesia, Analgesia, and Euthanasia of the Laboratory Zebrafish

35. Health Xurveillance Programs

36. Importation and Quarantine

37. Export and Transportation of Zebrafish

38. Regulations, Policies and Guidelines Pertaining to the Use of Zebrafish in Biomedical Research

III. Diseases

39. Water Quality and Idiopathic Diseases of Laboratory Zebrafish

40. Important Parasites of Zebrafish in Research Facilities

41. Bacterial and Fungal Diseases of Zebrafish

42. Viral Diseases

43. Nonexperimentally Induced Neoplastic and Proliferative Lesions in Laboratory Zebrafish

44. Special Procedures for Zebrafish Diagnostics

45. Zebrafish as a Model to Understand Vertebrate Development

46. Zebrafish as a Model for Revealing the Neuronal Basis of Behavior

47. Zebrafish as a Model to Understand Human Genetic Diseases

48. Zebrafiish as a Model for Investigating

49. Targeted Editing of Zebrafish Genes to Understand Gene Function and Human Disease Pathology

50. Zebrafish as a Platform for Genetic Screening

51. Zebrafish as a Platform for Drug Screening

Über Autor(innen)

Sanders, George E
George E. Sanders, DVM, M.S., is certified as a Fish Pathologist by the American Fisheries Society Fish Health Section, a Senior Lecturer, and the Aquatic Animal Program Director for the Department of Comparative Medicine at the University of Washington. He provides multiple resources, program development, facility and systems design, training, instruction, regulatory compliance, and coordinates veterinary care and pathology for all aquatic research animals. Dr. Sanders received his DVM from Louisiana State University School of Veterinary Medicine and his Masters of Science in Comparative Medicine from the Department of Comparative Medicine at the University of Washington.

Guillemin, Karen J
Karen Guillemin, Ph.D., earned her Doctorate at Stanford University. She is a Professor at the University of Oregon and a member of the Institute of Molecular Biology at Oregon. Dr. Guillemin studies host-microbe interactions in development and disease, and uses zebrafish in her research.

Kent, Michael L
Michael Kent, Ph.D., is a Professor of Microbiology at Oregon State University in the College of Veterinary Medicine. Kent's lab focuses on two major research areas: diseases of zebrafish in research facilities and impacts of pathogens on wild salmonid fishes. Dr. Kent is also a co-PI at the Zebrafish International Resource Center where he assists with health studies and their diagnostic service.

Cartner, Samuel
Samuel Cartner, D.V. M., Ph.D., is the Assistant Vice President for Animal Research Services and Director of the Animal Resources Program (ARP) at the University of Alabama at Birmingham (UAB). He received his DVM from Auburn College of Veterinary Medicine and PhD from UAB. Dr. Cartner has served in multiple roles with organizations that promote premium laboratory animal care. Dr. Cartner is a faculty member in the Department of Genetics. His research interest includes genetic susceptibility to infectious disease, and the development of animal models of human and animal disease. Recently Dr. Cartner has focused on investigations that lead to improvements of laboratory animal care and use.

Farmer, Susan F
Susan C. Farmer, DVM, Ph.D., is the Senior Clinical Veterinarian and Co-Director of the Zebrafish Research Facility at the University of Alabama. Services offered by the facility are husbandry, larviculture, cryopreservation and research support. Dr. Farmer have her DVM degree from Mississippi State University and her Ph.D. in Pathology/Experimental Pathology from the University of Alabama at Birmingham.

Eisen, Judith S
Judith S. Eisen, Ph.D., earned her Doctorate at Brandeis University. She is a professor at the University of Oregon and a member of the Institute of Neuroscience at Oregon. The focus of Eisen's research is to understand the mechanisms underlying development and function of the vertebrate nervous system. Eisen uses zebrafish in her research.