Drug Design

Cutting Edge Approaches
2. Erweitert und verbesserte Auflage Auflage 2002
ISBN: 978-0-85404-816-8
Verlag: RSC Publishing

Buch, Englisch, 202 Seiten, Format (B × H): 156 mm x 234 mm, Gewicht: 1026 g

Pharmaceutical research draws on increasingly complex techniques to solve the challenges of drug design. Bringing together a number of the latest informatics techniques, this book looks at modelling and bioinformatic strategies; structural genomics and X-ray crystallography; virtual screening; lead optimisation; ADME profiling and vaccine design. A number of relevant case studies, focussing on techniques that have demonstrated their use, will concentrate on G-protein coupled receptors as potential disease targets. Providing details of state-of-the-art research, Drug Design: Cutting Edge Approaches will be invaluable to all drug discovery scientists, including medicinal and combinatorial chemists, molecular modellers, bio- and chemoinformaticians, and pharmacologists, amongst others. University and pharmaceutical company libraries will also benefit from having a copy on their shelves.

Zielgruppe

Medicinal Chemists Researchers Molecular Modelers

Autoren/Hrsg.

Flower, Darren R

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Lebensmitteltechnologie und Getränketechnologie
• Naturwissenschaften Chemie Chemie Allgemein

Inhaltsverzeichnis

Introduction;

High-Throughput X-Ray Crystallography for Drug Discovery;

Bioinformatics in Drug Design: a GPCR case study;

Virtual Screening of Virtual Libraries - an Efficient Strategy for Lead Generation;

Virtual Techniques for Lead Optimisation;

The Impact of Physical Organic Chemistry on the Control of Drug-like Properties;

Mutagenesis and Modelling Highlight the Critical Nature of the TM2-loop-TM3 region of biogenic amine GPCRS;

Computational Vaccine Design;

Subject Index.