Glennon / Young Drug Discrimination

Applications to Medicinal Chemistry and Drug Studies
1. Auflage 2011
ISBN: 978-1-118-02314-3
Verlag: John Wiley & Sons
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 528 Seiten, E-Book

Drug discrimination: a practical guide to its contributions tothe invention of new chemical entities and evaluations of new orknown pharmacological agents
Drug discrimination can be described as a "drug detection"procedure that uses a pharmacologically active agent as thesubjective stimulus. Although the procedure does require someeffort to implement, it can be an extremely important tool forunderstanding drug action. Whereas medicinal chemists should cometo learn the types of information that drug discrimination studiescan offer, pharmacologists and psychologists might come to realizehow medicinal chemists can apply the types of information that theparadigm routinely provides. Drug Discrimination: Applications toMedicinal Chemistry and Drug Studies provides in-depth analyses ofthe nature and use of drugs as discriminative stimuli and bridgessome of the numerous gaps between medicinal chemistry,pharmacology, and psychology.
Stressing the practical aspects of drug discrimination,including types of procedures, study design, data, andinterpretation, the book details the advantages and limitations ofdrug discrimination studies versus other pharmacologic evaluations.Practical information from leading researchers in the fieldaddresses specific topics and techniques that are of interest indrug discovery, evaluation, and development.
A groundbreaking new guide to the applications of drugdiscrimination studies for medicinal chemistry and neuroscience,Drug Discrimination is essential for any scientist, researcher, orstudent whose interests involve the design, development, and/oraction of drugs acting at the level of the central nervoussystem.

Autoren/Hrsg.

Glennon, Richard A.

Young, Richard

Inhaltsverzeichnis

Part I.
Chapter 1. An Introduction to Drug Discrimination.
Chapter 2. Methodological Considerations.
Chapter 3. Drug Discrimination: Practical Considerations.
Chapter 4. Role of Stereochemistry in Drug Discrimination Studies.
Chapter 5. Drug Discrimination and In Vivo Structure-Activity Relationships.
Chapter 6. Drug Discrimination and Mechanisms of Drug Action.
Chapter 7. Drug Discrimination and Development of Novel Agents and Pharmacological Tools.
Part II.
Chapter 8. Perceptual Drug Discriminative Aspects of the Endocannabinoid Signaling System in Animals and Man (Torbjörn U. C. Järbe).
Chapter 9. Discriminative Stimulus Properties of Receptor Antagonists (Joseph H. Porter).
Chapter 10. The Discrimination of Drug Mixtures (P. Stolerman).
Chapter 11. Making the Right Choice: Lessons From Drug Discrimination for Research on Drug Reinforcement and Drug Self-Administration (S. Stevens Negus and Matthew L. Banks).
Chapter 12. Inhalant Drug Discrimination: Methodology, Literature Review and Future Directions (Keith L. Shelton and Robert L. Balster).
Chapter 13. Drug Discrimination Studies in Rhesus Monkeys: Drug Dependence and Withdrawal (Jun-Xu Li, Lisa R. Gerak, and Charles P. France).
Chapter 14. Human Drug Discrimination: Methodological Considerations and Application to Elucidating the Neurophar,acology of Amphetamines (Craig R. Rush, Andrea R. Vansickel, and William W. Stoops).
Chapter 15. Nicotine Discrimination in Humans (Kenneth A. Perkins).
Chapter 16. Drug Discrimination: A Perspective (Francis C. Colpaert).

Über Autor(innen)

Richard Glennon is Chair of the Department of MedicinalChemistry at Virginia Commonwealth University. He is the author ofover four hundred scientific publications and book chapters.
Richard Young is an Associate Professor in the Departmentof Medicinal Chemistry at Virginia Commonwealth University.Previously, he worked in the pharmaceutical industry at Ayerst andA. H. Robins (both now Pfizer).