Gondro / Hayes / van der Werf | Genome-Wide Association Studies and Genomic Prediction | Buch | 978-1-4939-5964-8 | sack.de

Buch, Englisch, Band 1019, 566 Seiten, Previously published in hardcover, Format (B × H): 178 mm x 254 mm, Gewicht: 10743 g

Reihe: Methods in Molecular Biology

Gondro / Hayes / van der Werf

Genome-Wide Association Studies and Genomic Prediction


Softcover Nachdruck of the original 1. Auflage 2013
ISBN: 978-1-4939-5964-8
Verlag: Humana Press

Buch, Englisch, Band 1019, 566 Seiten, Previously published in hardcover, Format (B × H): 178 mm x 254 mm, Gewicht: 10743 g

Reihe: Methods in Molecular Biology

ISBN: 978-1-4939-5964-8
Verlag: Humana Press


With the detailed genomic information that is now becoming available, we have a plethora of data that allows researchers to address questions in a variety of areas. Genome-wide association studies (GWAS) have become a vital approach to identify candidate regions associated with complex diseases in human medicine, production traits in agriculture, and variation in wild populations.  Genomic prediction goes a step further, attempting to predict phenotypic variation in these traits from genomic information.  Genome-Wide Association Studies and Genomic Prediction pulls together expert contributions to address this important area of study.  The volume begins with a section covering the phenotypes of interest as well as design issues for GWAS, then moves on to discuss efficient computational methods to store and handle large datasets, quality control measures, phasing, haplotype inference, and imputation.  Later chapters deal with statistical approaches to data analysis where the experimental objective is either to confirm the biology by identifying genomic regions associated to a trait or to use the data to make genomic predictions about a future phenotypic outcome (e.g. predict onset of disease). As part of the Methods in Molecular Biology series, chapters provide helpful, real-world implementation advice.
Gondro / Hayes / van der Werf Genome-Wide Association Studies and Genomic Prediction jetzt bestellen!

Zielgruppe


Professional/practitioner

Weitere Infos & Material


R for Genome-Wide Association Studies.- Descriptive Statistics of Data: Understanding the Data Set and Phenotypes of Interest.- Designing a Genome-Wide Association Studies (GWAS): Power, Sample Size, and Data Structure.- Managing Large SNP Datasets with SNPpy.- Quality Control for Genome-Wide Association Studies.- Overview of Statistical Methods for Genome-Wide Association Studies (GWAS).- Statistical Analysis of Genomic Data.- Using PLINK for Genome-Wide Association Studies (GWAS) and Data Analysis.- Genome-Wide Complex Trait Analysis (GCTA): Methods, Data Analyses, and Interpretations.- Bayesian Methods Applied to Genome-Wide Association Studies (GWAS).- Implementing a QTL Detection Study (GWAS) Using Genomic Prediction Methodology.- Genome-Enabled Prediction Using the BLR (Bayesian Linear Regression) R-Package.- Genomic Best Linear Unbiased Prediction (gBLUP) for the Estimation of Genomic Breeding Values.- Detecting Regions of Homozygosity to Map the Cause of Recessively Inherited Disease.- Use of Ancestral Haplotypes in Genome-Wide Association Studies.- Genotype Phasing in Populations of Closely Related Individuals.- Genotype Imputation to Increase Sample Size in Pedigreed Populations.- Validation of Genome-Wide Association Studies (GWAS) Results.- Detection of Signatures of Selection Using F.- Association Weight Matrix: A Network-Based Approach Towards Functional Genome-Wide Association Studies.- Mixed Effects Structural Equation Models and Phenotypic Causal Networks.- Epistasis, Complexity, and Multifactor Dimensionality Reduction.- Applications of Multifactor Dimensionality Reduction to Genome-Wide Data Using the R Package ‘MDR’.- Higher Order Interactions:Detection of Epistasis Using Machine Learning and Evolutionary Computation.- Incorporating Prior Knowledge to Increase the Power of Genome-Wide Association Studies.- Genomic Selection in Animal Breeding Programs.



Ihre Fragen, Wünsche oder Anmerkungen
Vorname*
Nachname*
Ihre E-Mail-Adresse*
Kundennr.
Ihre Nachricht*
Lediglich mit * gekennzeichnete Felder sind Pflichtfelder.
Wenn Sie die im Kontaktformular eingegebenen Daten durch Klick auf den nachfolgenden Button übersenden, erklären Sie sich damit einverstanden, dass wir Ihr Angaben für die Beantwortung Ihrer Anfrage verwenden. Selbstverständlich werden Ihre Daten vertraulich behandelt und nicht an Dritte weitergegeben. Sie können der Verwendung Ihrer Daten jederzeit widersprechen. Das Datenhandling bei Sack Fachmedien erklären wir Ihnen in unserer Datenschutzerklärung.