Drug Repurposing

Chemistry, Biochemistry & Red Biotechnology
1. Auflage 2025
ISBN: 978-1-032-71294-9
Verlag: CRC Press

Buch, Englisch, 200 Seiten, Format (B × H): 161 mm x 240 mm, Gewicht: 473 g

This volume is aimed at explaining how drug repurposing works; to what extent the initial hopes have been realised in finding drugs for neurodegenerative diseases, psychiatric disorders, cancer and diseases caused by parasitic worms. Drug repurposing also has had some success in treating bacterial infections. Multi-drug resistance has emerged as a great challenge in the drug development area. Drug repurposing may help there as well; this has been discussed in the context of TB. Like in many other areas, nano-materials have been helpful in formulating drugs for repurposing.

The first chapter points out that [a] drug repurposing heralds the demise of the magic bullet concept of drug actions [b] both partners in a drug-target pair are promiscuous and drug repurposing is a subset of polypharmacology.

The last chapter talks of vaccine repurposing. Considerable data now exist which makes a compelling case for including this exciting topic.

This book is a fair mix of success stories, a reality check on the status of this approach and challenges ahead in this area.

Zielgruppe

Academic and Postgraduate

Autoren/Hrsg.

Gupta, M N

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Biochemie (med.)
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Wirtschaftswissenschaften Wirtschaftssektoren & Branchen Fertigungsindustrie Pharmaindustrie

Inhaltsverzeichnis

Preface. 1. Polypharmacology: Drug Promiscuity Enabled by Protein Promiscuity. 2. Approaches to Identify and Repurpose Drugs for Neurodegenerative Diseases. 3. Drug Repurposing for Psychiatric Diseases. 4. Drug Repurposing as a Novel Approach to Cancer Treatment. 5. Anticancer Drugs for Repurposing Against Gram-Negative and Gram-Positive Bacterial Infections. 6. Repurposing Drugs for Effective Treatment of Tuberculosis: A Promising Approach. 7. Repurposing Drugs as Anthelmintics: Expanding the Therapeutic Arsenal Against Parasitic Worm Infections. 8. Applications of Nanomaterials for Drug Repurposing. 9. A Review of the Use of Existing Vaccines as a First Line of Defense in the SARS-CoV-2 Pandemic. Index.

Über Autor(innen)

Munishwar Nath Gupta taught chemistry, biochemistry and biotechnology at IIT Delhi [1975-2018]. A PhD in biochemistry from IISc Bangalore was followed by post-docs at University of Minnesota, USA; MIT, USA; UTC, France and Lund University, Sweden. He is a fellow of NASI, Allahabad and INSA, New Delhi. He has published over 300 scientific articles and edited 7 books so far. His current h-index is 63.