Lipids in Protein Misfolding

Softcover Nachdruck of the original 1. Auflage 2015
ISBN: 978-3-319-37205-1
Verlag: Springer International Publishing

Buch, Englisch, Band 855, 260 Seiten, Paperback, Format (B × H): 178 mm x 254 mm, Gewicht: 5859 g

Reihe: Advances in Experimental Medicine and Biology

Protein conversion from a water-soluble native conformation to the insoluble aggregates and fibrils, which can deposit in amyloid plaques, underlies more than 20 human diseases, representing a major public health problem and a scientific challenge. Such a conversion is called protein misfolding. Protein misfolding can also involve errors in the topology of the folded proteins and their assembly in lipid membranes. Lipids are found in nearly all amyloid deposits in vivo, and can critically influence  protein misfolding in vitro and in vivo in many different ways. This book focuses on recent advances in our understanding of the role of lipids in modulating the misfolding of various proteins. The main emphasis is on the basic biophysical studies that address molecular basis of protein misfolding and amyloid formation, and the role of lipids in this complex process.

Zielgruppe

Research

Autoren/Hrsg.

Gursky, Olga

Fachgebiete

• Naturwissenschaften Chemie Organische Chemie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien
• Naturwissenschaften Biowissenschaften Proteinforschung
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
• Naturwissenschaften Biowissenschaften Lipidologie

Inhaltsverzeichnis

Role of Lipids in Folding, Misfolding and Function of Integral Membrane Proteins.- Protein Misfolding in Lipid-Mimetic Environments.- Lipids in Amyloid-ß Processing, Aggregation, and Toxicity.- Role of Cholesterol and Phospholipids in Amylin Misfolding, Aggregation and Etiology of Islet Amyloidosis.- Stability, Oligomerization, and Amyloidogenicity of Apo Serum Amyloid A.- Interactions of Lipid Membranes with Fibrillar Protein Aggregates.- The Role of Lipid in Misfolding and Amyloid Fibril Formation by Apolipoprotein C-II.- Amyloid-Forming Properties of Human Apolipoproteins: Sequence Analyses and Structural Insights.- Computational Approaches to Identification of Aggregation Sites and the Mechanism of Amyloid Growth.- Role of Syndecans in Lipid Metabolism and Human Diseases.