Carbohydrates in Drug Design and Discovery

Erscheinungsjahr 2015
ISBN: 978-1-84973-939-9
Verlag: RSC Publishing

Buch, Englisch, Band 43, 320 Seiten, Format (B × H): 163 mm x 236 mm, Gewicht: 635 g

Reihe: Drug Discovery

In recent years there has been increasing evidence of the importance of carbohydrates and glycoconjugates in biomedical applications, and the use of synthetic ligands based on carbohydrates as drugs has received much attention. Focussing on drug discovery from key targets and placing an emphasis on the multi-disciplinary approaches necessary to challenge these issues, this book comprehensively covers the new and recent discoveries in the area of carbohydrate drug discovery.

Carbohydrates in Drug Design and Discovery is split into five sections, beginning with a introduction and perspective on the current market. The book then goes on to discuss new synthetic methods in glycobiology, the use of glycobiology in chemical biology and glycobiology in drug discovery.

Providing a worldwide perspective on this broad area, and providing examples of therapeutics already developed using these methods, this book provides a comprehensive introduction, discussion and update on this fast developing field for medicinal chemists and biochemists working in industry and academia.

Autoren/Hrsg.

Jimenez-Barbero, Jesus

Canada, F. Javier

Martin-Santamaria, Sonsoles

Weitere Mitwirkende

Martinez, Ana

Thurston, David

Marradi, Marco

Huang, Xuefei

Molinaro, Antonio

Silipo, Alba

Penades, Soledad

Roy, Rene

Schweizer, Frank

Vincent, Stéphane

Mulard, Laurence

Pilar Rauter, Amelia

Nativi, Cristina

Baasov, Timor

Bencomo, Vicente Verez

Jimenez-Barbero, J

Siriwardena, Aloysius

Nigou, Jérôme

Davis, Ben

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien
• Naturwissenschaften Biowissenschaften Chemische Biologie, Synthetische Biologie
• Naturwissenschaften Biowissenschaften Kohlenhydrate
• Naturwissenschaften Chemie Organische Chemie Biochemie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie

Inhaltsverzeichnis

Tumor associated carbohydrate antigens; Lipopolysaccharides as microbe-associated molecular patterns; Carbohydrate protein interactions at the host-pathogen interface; Glyconanotechnology and disease; Glycodendrimers for drug discovery; Chemical glycobiology of infection; Glycosylated antitumor ether lipids; Synthesis of novel molecules for glycobiology and glycomedicine; The development of innovative strategies towards glycovaccines; Carbohydrates and glycomimetics in neurodiseases; Glycosyl-containing inhibitors of Matrix Metallo Proteinases; Design and synthesis of novel molecules as mechanistic probes for carbohydrate-mediated biological recognition; The development of the Haemophilus influenzae type b (Hib) vaccine using a synthetic antigen; Carbohydrate-Protein Interactios: A 3D view by NMR and modeling; Inhibition of enzyme activity (glycosides and gycosyl hydrolase enzymes) using multivalent analogs; Mycobacterium tuberculosis and C-type lectins; New tools for chemical medicine: From synthesis to applications