Koch-Nolte Endogenous ADP-Ribosylation

2015
ISBN: 978-3-319-10771-4
Verlag: Springer International Publishing
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 384, 213 Seiten, eBook

Reihe: Current Topics in Microbiology and Immunology

This volume gathers the latest exciting findings on ADP-ribosylation from renowned experts in the field. It includes ten chapters, organized into the following three thematic sections:· Evolution and detection of endogenous ADP-ribosylation· ADP-ribosylation by the ARTC family of ADP-ribosyltransferases (R-S-E ARTs)· ADP-ribosylation by the ARTD family of ADP-ribosyltransferases (H-Y-E ARTs)The book will provide readers a better understanding of ADP-ribosylating toxins and their endogenous relatives. This provides a basis for developing novel toxin-neutralizing drugs and drugs targeting endogenous ADP-ribosyltransferase relatives.

Zielgruppe

Research

Autoren/Hrsg.

Koch-Nolte, Friedrich

Inhaltsverzeichnis

Part I: Evolution and Detection of Endogenous ADP-Ribosylation The natural history of ADP-ribosyltransferases and the ADP ribosylation systemL. Aravind, Dapeng Zhang, Robson F. de Souza, Swadha Anand and Lakshminarayan M. Iyer Identification and Analysis of ADP-ribosylated ProteinsFriedrich Haag and Friedrich Buck Part II: ADP-Ribosylation by ARTCs (R-S-E ARTs) Photorhabdus luminescens toxins TccC3 and TccC5: Insecticidal ADP-ribosyltransferases that modify threonine and glutamineKlaus Aktories, Gudula Schmidt and Alexander E. Lang Reaction mechanism of mono-ADP-ribosyltransferase based on structures of the complex of enzyme and substrate proteinHideaki Tsuge, Toshiharu Tsurumura Regulation of nitrogenase by reversible mono-ADP-ribosylationVivian R. Moure, Flavia F. Costa, Leonardo M. Cruz, Fabio O. Pedrosa, Emanuel M. Souza, Xiao-Dan Li, Fritz Winkler and Luciano F. Huergo ADP-ribosylation of P2X7: a matter of life and death for regulatory T cells and natural killer T cellsBjörn Rissiek, Friedrich Haag, Olivier Boyer, Friedrich Koch-Nolte, Sahil Adriouch Pierisins and CARP-1: ADP-ribosylation of DNA by ARTCs in butterflies and shellfishTsuyoshi Nakano, Azusa Takahashi-Nakaguchi, Masafumi Yamamoto, and Masahiko Watanabe Part III: ADP-Ribosylation by ARTDs (H-Y-E ARTs) Comparative structural analysis of the putative mono-ADP-ribosyltransferases of the ARTD/PARP familyAna Filipa Pinto and Herwig Schüler Function and regulation of the mono-ADP-ribosyltransferase ARTD10Max Kaufmann, Karla L. H. Feijs, and Bernhard Lüscher Regulation of nucleocytoplasmic transport by ADP-ribosylation: the emerging role of karyopherin-ß1 mono-ADP-ribosylation by ARTD15Maria Di Girolamo

Über Autor(innen)

Friedrich Koch-Nolte is a professor at University Hospital Hamburg-Eppendorf, Institute for Immunology, Hamburg, Germany