Deep Brain Stimulation

Indications and Applications
1. Auflage 2016
ISBN: 978-981-4669-89-4
Verlag: Pan Stanford Publishing Pte Ltd

Buch, Englisch, 486 Seiten, Format (B × H): 315 mm x 160 mm, Gewicht: 1060 g

Deep brain stimulation (DBS) is a widely used therapy for movement disorders such as Parkinson's disease, essential tremor, and dystonia. Its therapeutic success has led to the application of DBS for an increasing spectrum of conditions. However, the fundamental relationships between neural activation, neurochemical transmission, and clinical outcomes during DBS are not well understood.

Drawing on the clinical and research expertise of the Mayo Clinic Neural Engineering Laboratories, this book addresses the history of therapeutic electrical stimulation of the brain, its current application and outcomes, and theories about its underlying mechanisms. It reviews research on measures of local stimulation–evoked neurochemical release, imaging research on stimulation-induced neural circuitry activation, and the state of the art on closed-loop feedback devices for stimulation delivery.

Zielgruppe

Academic and Postgraduate

Autoren/Hrsg.

Lee, Kendall H.

Duffy, Penelope S.

Bieber, Allan J.

Fachgebiete

• Naturwissenschaften Biowissenschaften Biowissenschaften
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Chirurgie Neurochirurgie

Inhaltsverzeichnis

Introduction to Deep Brain Stimulation. Overview of the History and Application of Deep Brain Stimulation. Biophysical Fundamentals of Neural Excitation. Motor Circuit Activity in Parkinson’s Disease. Neuroimaging in Deep Brain Stimulation. Ethical Considerations in the Use of Deep Brain Stimulation. Clinical Applications. Deep Brain Stimulation for Parkinson’s Disease. Deep Brain Stimulation for Tremor. Deep Brain Stimulation for Dystonia. Deep Brain Stimulation for Obsessive–Compulsive Disorder. Deep Brain Stimulation for Tourette Syndrome. Deep Brain Stimulation for Treatment-Resistant Depression. Deep Brain Stimulation for Chronic Pain. Deep Brain Stimulation for Medically Refractory Epilepsy. Deep Brain Stimulation for Memory Dysfunction. Deep Brain Stimulation for Cluster Headache. Functional Electrical Stimulation for Spinal Cord Injury. Research on Mechanisms of DBS and Neuromodulation. Theories of Deep Brain Stimulation Mechanisms. The Role of Astrocytes in Deep Brain Stimulation. Electrochemical Measurements of Neurochemical Concentration. Electrodes for Neural Stimulation and Monitoring. Closed-Loop Control Systems for Deep Brain Stimulation Therapy. Molecular and Cellular Neuromodulation for Central Nervous System Injury.

Über Autor(innen)

Kendall H. Lee is a stereotactic and functional neurosurgeon at Mayo Clinic with internationally recognized expertise in deep brain stimulation. His MD and PhD are from Yale University. He is a professor in the Departments of Neurosurgery, Physiology & Biomedical Engineering, and Physical Medicine and Rehabilitation. He is director of the Neural Engineering Laboratories, focused on understanding the mechanisms of action of DBS and developing novel devices for neuromodulation.

Penelope S. Duffy is an associate director of the Neural Engineering Laboratories at Mayo Clinic with a PhD from the University of Minnesota. Dr. Duffy had a 27-year research and clinical career in neurologically based communication disorders and is the author of a graduate textbook on right hemisphere cognitive impairments. She has scientific papers in that area and in deep brain stimulation, and two books in the trade press.

Allan J. Bieber is an associate professor of Neurologic Surgery, associate director of the Neural Engineering Laboratories and of the Neurobiology of Disease Graduate Program in the Mayo Clinic College of Medicine. His PhD is in cellular and developmental biology from Harvard Medical School.