Letts / Morgan Inflammatory Processes:

Molecular Mechanisms and Therapeutic Opportunities
2000
ISBN: 978-3-0348-8468-6
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 144 Seiten, eBook

Reihe: Progress in Inflammation Research

In November 1998 many of the key leaders of new drug discovery for

inflammatory diseases gathered at Hershey, Pennsylvania for the 9th

International Conference of the Inflammation Research Association. The

Conference was held over a five day period and provided a stimulating

environment for the open exchange of important advances in basic

inflammation research as well as new drug discovery and development.

This book encompasses some of the highlights of several presentations

made at the Conference. It contains some of the latest and important

developments in the field of inflammation research.

Topics include the status of eotaxin and chemokines in asthma and

allergy, signal transduction and regulation of diverse mediators such as

the JNK group of MAP kinases, TNF and IL-1 signaling of NF-kB as well as

regulators of AP-1, macrophage metalloproteinases, lymphotoxin and

further insights into the role of MCP-1 in disease. Also discussed are

drug targets in rheumatoid and osteoarthritis, fibrotic diseases,...

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Letts, L. Gordon

Morgan, Douglas W.

Inhaltsverzeichnis

Contents. List of Contributors. Preface. T.J. Mitchell and T.J. Williams: The role of eotaxin and related CC-chemokines in asthma and allergy. Roger J. Davis: Signal transduction by the JNK group of MAP kinases. Marie Chabot-Fletcher: TNF and IL-1 signaling to NF-kB. Anthony M. Manning: Small molecule regulators of AP-1 and NF-kB. Robert T. Abraham: Mammalian target of rapamycin: Immunosuppressive drugs offer new insights into cell growth regulation. Catherine A. Burton, John Boylan, Candy Robinson, Janet Kerr and Pamela Benfield: Constitutive expression of a tumor suppressor leads to tumor regression in a xenograft model. Steven D. Shapiro: Macrophage metalloproteinases in destructive inflammatory diseases. Nancy H. Ruddle: Lymphotoxin in inflammation and lymphoid organ development: Variations on a theme. Steven L. Kunkel, Sem H. Phan, Nicholas W. Lukacs, Cory Hogaboam and Stephen W. Chensue: Chemokine/cytokine biology during the evolution of fibrotic disease. Long Gu, Susan C. Tseng and Barrett J. Rollins: The role of MCP-1 in disease. Lisa A. Beck, Cristiana Stellato, Syed Shahabuddin, Renate Nickel and Robert P. Schleimer: The role of chemokines in allergic diseases of the airways. James Winkler and Ken Tramposch (coordicators): Ninth International Conference of the Inflammation Research Association, November 1-5, 1998: Summaries of workshops and poster discussions. William Williams and Elizabeth Arner (chair persons): Targets in rheumatoid and osteoarthritis. Lawrence Wennogle and Nancy Cusack (chair persons): Signal transduction and regulation of gene expression. James Burke and Floyd Chilton (chair persons): Mediators in inflammation and their enzymes. Denis Schrier and Fandrew Issekutz (chair persons): Cell adhesion molecules and leukocyte trafficking. Robert M. Strieter and David Underwood (chair persons): Pulmonary inflammation, fibrosis, and disease. W. Hunter and E. Turley (chair persons): Angiogenesis, wound repair and skin inflammation. Index.