Natural Product Drug Discovery

Highly Anticipated Natural Molecules
Erscheinungsjahr 2026
ISBN: 978-0-443-40578-5
Verlag: Elsevier Science

Buch, Englisch, 450 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 450 g

Natural Product Drug Discovery: Highly Anticipated Natural Molecules provides a comprehensive examination of the role of natural products in innovative drug development. This research level reference addresses the significant challenges that highly active natural molecules face in the drug development process, including issues related to bioavailability and potency. The book presents detailed analyses of various classes of natural products, including polysaccharides, volatile oils, and diterpenoids, exploring their chemical properties, biological activities, and potential clinical applications. Each chapter is authored by leading experts in the field, offering insights into structural modification techniques, naturally sourced inhibitors, and the application of green biomanufacturing strategies to enhance drug development. This volume in the Drug Discovery Opinion series serves as an essential resource for researchers, pharmacologists, and industry professionals involved in natural product drug discovery. It provides the necessary information to navigate the complexities of this field, emphasizing the integration of traditional knowledge with modern scientific approaches. Through a thorough understanding of these natural compounds, this book aims to contribute to the advancement of therapeutic innovations in pharmacotherapy.

Autoren/Hrsg.

Li, Ning

Yang, Liu

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

1. Highly Anticipated Natural Molecules
2. The Key Technology in Drug Discovery: Structural Modification of Natural Products
3. Naturally Sourced Sodium-Glucose Co-transporter 2 Inhibitors for Hypoglycemic: From Phlorizin to Dapagliflozin
4. Polysaccharides from TCM as an Important Resource of New Drugs for Antiosteoporosis and Neurodegenerative Diseases
5. Drug Discovery from Daphnane-type Diterpenoids: A Balance Between the Anti-HIV Effect and Toxicity
6. The Promising Future of Sesquiterpenoids: A Potential Source of New Drugs
7. Tussilagone as a Potential Therapeutic Candidate Against Inflammation-Related Diseases
8. Right Time for Drug Development from Volatile Oils
9. Natural Products in Alzheimer's Disease
10. The Discovery, Synthesis, and Bioactivities of Marine Sesquiterpene Hydroquinones/Quinones
11. Cardiac Glycoside: A Potential Antineoplastic Candidate from a Medication of Heart Failure and Atrial Arrhythmia
12. Natural Products as Potential Neuroprotective Agents for Ischemic Stroke
13. Key Strategy for Drug Development: Green Biomanufacturing of Active Natural Products
14. Research and Development of the Anti-Tumor Star Molecule Taxol
15. Bile Acids: Dual Facets as Modulators and Targets in Natural Product Drug Discovery
16. Natural Cephalotane Alkaloids from Cephalotaxaceae as a Source of New Anticancer Drugs
17. Computation-Enabled Natural Products Drug Discovery
18. Active Metabolites Derived from Microorganisms of Extreme Environments

Über Autor(innen)

Li, Ning
Professor Ning Li is the associate dean of Chinese Materia Medica of Shenyang Pharmaceutical University, the "Youth talent" of Liao Ning Revitalization Talents Program, the "Talent of Hundred level" of Liaoning Bai Qian Wan Talents Program, the "Leading talent" of both Shenyang High-Level Talent Program and Xinjiang Uygur Autonomous Region. She has focused on the research of chemoprevention of critical diseases, especially the neurodegenerative disease and cancer, through post-transcriptional mechanism on the perspective view of 'preventive treatment strategy' of the Traditional Chinese theory. She has hosted seven projects of National Natural Science Foundation of China and published more than 120 SCI papers on famous academic journals, born several prizes like the "First Prize of Provincial Science and technology progress award", and obtained the authorization of 20 invention patents.

Yang, Liu
Professor Liu Yang, currently serves as the Dean of the School of Pharmaceutical Engineering, the Chairman of the Pharmaceutical Engineering Discipline and the Chairman of the Biology and Medicine Discipline at Shenyang Pharmaceutical University, P. R. China. He received his Bachelor and Master Degrees from Hunan University, and Doctoral Degree from Shenyang Pharmaceutical University. Professor Liu has been engaged in innovative research of medicinal chemistry for a long time, leading his group to carry out researches on innovative drugs and modified new drugs for treatment of malignant tumors, diabetes, AD and other major diseases, developing drug preparation technologies suitable for industrial production, and promoting the industrialization of project implementation. He has published over 120 research papers, authored 8 books, and applied for 18 invention patents. He has been selected into the Outstanding Young Scholars in Liaoning Province and the Innovative Talents in Liaoning Province, and has won the first prize for science and technology progresses in Liaoning Province.