Macieira-Coelho Signaling Through the Cell Matrix

2000
ISBN: 978-3-642-59766-4
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 25, 136 Seiten, eBook

Reihe: Progress in Molecular and Subcellular Biology

Zielgruppe

Research

Autoren/Hrsg.

Macieira-Coelho, Alvaro

Inhaltsverzeichnis

Topological Constraints Carry Signaling from the Cell Matrix to the Genome.- 1 Variation in Cell Adhesion During Proliferation of Normal Cells.- 1.1 Coupling Between Changes in Cell Adhesion and Proliferation of Normal Cells.- 2 Coupling Between Changes in Cell Adhesion and Proliferation of Transformed Cells.- 3 Mechanisms of Cell Adhesion-Mediated Changes in the Cell Phenotype.- 3.1 Modulation of Cell Proliferation.- 3.2 Modulation of Malignancy.- 3.3 Modulation of Cell Differentiation.- 4 Conclusions.- References.- The Transmission of Contractility Through Cell Adhesion.- 1 Introduction.- 2 Generation of Contractility.- 2.1 Stress Fibers.- 2.2 Formation of Stress Fibers and Focal Adhesions.- 3 Molecular Mechanism of Force Transmission.- 3.1 Focal Adhesions.- 3.2 Mechanism of Force Transmission.- 3.3 Molecules Mediating Force Transmission.- 4 Regulation of Contractility Transmission.- 4.1 Regulation of Contractile Force.- 4.1.1 The Regulatory Mechanism of RhoA.- 4.1.2 Involvement of Microtubules.- 4.2 Regulation of Stability of Focal Adhesions.- 5 Interaction Between Contraction Force and ECM.- 6 Myofibroblasts and Wound Healing.- 7 Muscle.- 7.1 Myotendinous Junctions.- 7.2 Costameres.- 7.2.1 Contraction Force Transmission at Costameres.- 7.2.2 Potential Involvement of Dystrophin.- 7.2.3 Significance of Costameres in Heart Function.- 8 Conclusion.- References.- Role of Focal Adhesion Kinase in Signaling by the Extracellular Matrix.- 1 Introduction.- 2 FAK Activation by Integrin.- 2.1 FAK Interaction with Integrin.- 2.2 FAK Interaction with Cytoskeletal Proteins Talin, Paxillin, and Tensin.- 3 FAK Downstream Pathways.- 3.1 FAK Interaction with Src.- 3.2 FAK Interaction with PI 3-Kinase.- 3.3 FAK Interaction with p130cas.- 4 Biological Functions of FAK in Signaling by ECM.- 4.1 Cell Adhesion and Spreading.- 4.2 Cell Migration.- 4.3 Cell Survival and Apoptosis.- 4.4 Cell Cycle Progression and Proliferation.- References.- Interaction Between Cells and Extracellular Matrix: Signaling by Integrins and the Elastin-Laminin Receptor.- 1 Introduction.- 2 Cell-Matrix Interactions Mediated by Integrins.- 2.1 Signaling by Integrins.- 2.2 Evolution of Integrin Signaling with Aging.- 3 Cell-Matrix Interactions Mediated by the Elastin-Laminin Receptor.- 3.1 Signaling by the Elastin-Laminin Receptor.- 3.2 Effect of Age on the Elastin-Laminin Receptor.- 3.3 Experiments on Lymphocytes.- 4 Discussion and Conclusions.- References.- Regulation of Gene Expression by Changes in Cell Adhesion.- 1 Introduction.- 2 Regulation of Cell Proliferation by Cell Adhesion.- 2.1 Regulation of the G1 Phase.- 2.2 Molecular Basis for Regulation of the G1/S Transition.- 2.3 Regulation of Cycling A Gene Expression.- 3 Regulation of Cell Differentiation by Cell Adhesion.- 3.1 Differentiation of Hepatocytes and Regulation of Albumin Gene Expression.- 3.2 Differentiation of Mammary Epithelial Cells and Regulation of ß-Casein Gene Expression.- 4 Conclusion.- References.- Expression of Liver Specific-Genes in Hepatocytes Cultured in Collagen Gel Matr.- 1 Introduction.- 2 Culture of Hepatocytes in Collagen Gel.- 3 Hepatic Specific Functions of Hepatocytes in Collagen Cultures.- 4 Biotransformation Capability: Basal and Induced Levels of Drug-Metabolizing Enzymes.- 5 Expression of Hepatic Transcription Factors.- 6 Concluding Remarks.- References.- Collagen Type I: A Substrate and a Signal for Invasion.- 1 Introduction.- 2 Invasion into Matrices.- 2.1 The Structure of Collagen Type I.- 2.2 Technical Aspects: Different Collagen Type I Invasion Assays.- 2.3 Substrate-Dependent Differences in Invasion.- 3 Effects of Collagen on the Invasive Behavior of Cells.- 3.1 Collagen Conformation.- 3.2 Organization of the Invade/Collagen Microecosystem.- 3.3 Invasion of Cells Without External Stimuli Other Than Collagen Type I.- 3.4 Invasion, Angiogenesis, and Morphogenesis Assisted by Helper Cells.- 3.5 Invasion Stimulated by Extrinsic Factors.- 4 A Scenario for the Molecular Cross Talk Between Collagen and Cell.- 5 Conclusion.- References.