The Common Marmoset in Captivity and Biomedical Research

Erscheinungsjahr 2018
ISBN: 978-0-12-811829-0
Verlag: Elsevier Science

Buch, Englisch, 570 Seiten, Format (B × H): 218 mm x 286 mm, Gewicht: 1770 g

The Common Marmoset in Captivity and Biomedical Research is the first text dedicated exclusively to this species,filling an urgent need for an encyclopedic compilation of the existing information. Sponsored by the American College of Laboratory Animal Medicine as part of its authoritative Blue Book series, the book covers the biology,management, diseases, and clinical and research applications of this important species. The common marmoset (Callithrix jacchus) has come of age in the scientific community as a behaviorally complex, cognitively advanced,small, prolific, and easily maintained nonhuman primate with many of the advantages of larger animals, such as macaques, but without the attendant physical and zoonotic risks.

Marmosets are currently being used in diverse areas of inquiry, including vision and auditory research, infectious disease, cognitive neuroscience, behavior, reproductive biology, toxicology and drug development, and aging. The marmoset genome has been sequenced and there is currently an intensive effort to apply gene editing technologies to the species. The creation of transgenic marmosets will provide researchers with a small nonhuman primate model to study a number of poorly understood disorders, like autism.

Zielgruppe

<p>vivarium professionals maintaining marmoset colonies, veterinarians responsible for their care and well-being, zoologists and ethologists studying the species, and investigators using them to gain critical insights into human physiology and disease. </p>

Autoren/Hrsg.

Marini, Robert P

Wachtman, Lynn M

Tardif, Suzette D

Mansfield, Keith

Fox, James G

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Labormedizin
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien

Inhaltsverzeichnis

Section I: BIOLOGY AND MANAGEMENT 1. Taxonomy and Natural History 2. The Anatomy of the Common Marmoset 3. Neuroanatomy of the Marmoset 4. Marmoset Nutrition and Dietary Husbandry 5. Husbandry and Housing of Common Marmosets 6. Normal Clinical and Biological Parameters of the Common Marmoset (Callithrix jacchus) 7. Behavior and Behavioral Management 8. Reproduction, Growth, and Development 9. Regulatory Considerations

Section II: DISEASES AND CLINICAL APPLICATIONS 10. Physical Examination, Diagnosis, and Common Clinical Procedures 11. Anesthesia and Common Surgical Procedures 12. Diseases of the Urogenital System 13. Diseases of the Gastrointestinal System 14. Bone, Muscle, and Skeletal Disease 15. Viral Diseases of Common Marmosets 16. Bacterial Diseases 17. Parasitic Diseases 18. Neoplastic Diseases

Section III: RESEARCH AND APPLICATIONS 19. The Genome of the Common Marmoset 20. Creating Genetically Modified Marmosets 21. Marmosets in Aging Research 22. The Marmoset Monkey as a Model for Visual Neuroscience 23. Marmosets in Neurologic Disease Research: Parkinson's Disease 24. Experimental Autoimmune Encephalomyelitis in the Marmoset as a Translational Model for Multiple Sclerosis 25. Marmosets in Auditory Research 26. The Marmoset as a Model in Behavioral Neuroscience and Psychiatric Research 27. The Use of the Marmoset in Toxicity Testing and Nonclinical Safety Assessment Studies 28. Experimental Infections of the Common Marmoset (Callithrix jacchus) 29. Insights Gained from Marmoset Endocrine Research

Über Autor(innen)

Marini, Robert P
Robert P. Marini, DVM, DACLAM, Assistant Director, is a member of MIT's Division of Comparative Medicine's clinical staff and is Chief of the Division's clinical surgical facilities. Dr. Marini is responsible for coordinating and supervising all major survival surgery in non-rodent mammalian species.

Fox, James G
Prof. James G. Fox obtained his Doctor of Veterinary Medicine at Colorado State University, Fort Collins, and, as an NIH postdoctoral fellow, received a Master of Science in Medical Microbiology at Stanford University. Dr. Fox is an adjunct professor at Tufts University School of Veterinary Medicine. He is a diplomate and a past president of the American College of Laboratory Animal Medicine, as well as a past president of the Massachusetts Society for Medical Research and the American Association of Veterinary Medical Colleges. Additionally, he has served as past chairman of the AAALAC Council and the NCCR/NIH Comparative Medicine Study Section. He is also an elected fellow of the Infectious Disease Society of America and the American Gastroenterological Association. He was recruited to MIT and created the Division of Comparative Medicine, which he directed from 1974 until 2021. As a faculty member in the MIT Department of Biological Engineering, Professor Fox received numerous scientific awards and was elected to the National Academy of Medicine in 2004. Dr. Fox has been the principal investigator of an NIH postdoctoral training grant for veterinarians for 30 years and has trained 90 veterinarians for careers in biomedical research. The NIH has continuously funded him to study infectious diseases of the gastrointestinal tract, where he has studied the gastrointestinal microbiome and how it interfaces with and influences the host's immune response to gastrointestinal pathogens, particularly oncogenic Helicobacter species. He has authored over 600 papers, 84 chapters, holds 4 patents and has authored or edited 18 comparative medicine texts.

Mansfield, Keith
Keith Mansfield is Associate Director for Resource and Collaborative Affairs and Chair, Division of Primate Resources, New England National Primate Research Center, Harvard Medical School, Harvard University, Southborough, US. His research focuses on primarily on the recognition of spontaneously occurring infectious diseases of nonhuman primates and their development into novel animal models to investigate disease pathogenesis.

Tardif, Suzette D
Suzette D. Tardif, Ph.D., is the Associate Director of Research at the Southwest National Primate Research Center. She is an adjunct faculty of The Barshop Institute. The Tardif laboratory's activities center on the development of the marmoset monkey as a disease model. Dr. Tardiff is a past-President of the American Society of Primatologists.

Wachtman, Lynn M
Harvard Medical School, Boston MA USA