Microbiome in Neurological Conditions: Biology, Mechanisms, and Diagnostic Approach

Erscheinungsjahr 2025
ISBN: 978-0-443-31648-7
Verlag: Elsevier Science & Technology

Buch, Englisch, Format (B × H): 152 mm x 229 mm, Gewicht: 450 g

Microbiome in Neurological Conditions, Volume 180, the latest release in the International Review of Neurobiology series, highlights new advances in the field, with this volume presenting insightful chapters written by an international board of authors. Chapters in this volume explore the role of microbiome dysbiosis in neurological and psychiatric disorders, including its influence on neurochemical production in Parkinson’s Disease, immune system dysregulation in Huntington’s Disease, and alterations in the enteric neuromuscular system in Amyotrophic Lateral Sclerosis.

Other chapters examine the impact of microbial imbalances on psychiatric conditions such as schizophrenia, bipolar disorder, depression, and ADHD, along with the effects of perinatal antibiotic exposure and microbiome-based dietary supplements on brain health. This volume also delves into bacterial and viral infections linked to neuroinflammation and neuromuscular impairments, as well as maternal infections contributing to congenital neurological conditions. Offering a comprehensive perspective on the microbiome’s role in brain function and disease, this book provides valuable insights for researchers, clinicians, and those interested in the intersection of microbiology and neurology.

Autoren/Hrsg.

Weitere Mitwirkende

Sevanan, Murugan

Manikkoth, Shyamjith

Vani, Chandrapragasam

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft

Inhaltsverzeichnis

1. Dysbiosis significantly elevates the probability of altered affective function in Alzheimer's Disease (AD)
2. Intestinal Dysbiosis leads to reduction in Neurochemical production in Parkinson’s Disease (PD)
3. Microbiota dysbiosis impact on the immune system dysregulation in Huntington's disease (HD)
4. Altered microbiome influence on the enteric neuromuscular system in Amyotrophic Lateral Sclerosis (ALS)
5. Oro-pharyngeal mucosal microbiome alterations causing immune system dysregulation in Schizophrenia
6. Disruption in the human microbiome causing behavioral changes in Bipolar Disorder
7. The role of Microbiome in Gut-Brain-Axis dysbiosis causing Depression: from Mechanisms to Treatment
8. Microbial imprints: The role of secondary genomes in neurodevelopment and co-evolutionary dynamics
9. Abnormal microbiota due to perinatal antibiotic exposure as a possible risk factor for Attention-Deficit / Hyperactivity Disorder (ADHD)
10. Microbiome-based dietary supplements for better development and a healthy brain
11. Bacterial meningitis as a significant catalyst for neuroinflammation
12. Pathogenic viruses and neuromuscular impairments: A new frontier in neurovirological research
13. Retrospective link of altered mental status and cryptococcal meningitis
14. Acute disseminated encephalomyelitis - a monophasic illness
15. Maternal exposure to Rubella infection elevates risk of Congenital Rubella Syndrome (CRS)

Über Autor(innen)

Sevanan, Murugan
Dr. S. Murugan is an esteemed Associate Professor in the Department of Biotechnology at Karunya Institute of Technology and Sciences, a distinguished Deemed University situated in Coimbatore. He boasts a rich academic background, holding an M.Sc. in Microbiology from Manonmaniam Sundaranar University and a Ph.D. in Microbiology from Bharathiar University.

His illustrious career spans over 25 years, during which he has exhibited profound dedication to the realm of education. Dr. Murugan's scholarly contributions are remarkable, encompassing 72 research articles, 5 articles pertaining to career development, and 7 general articles in esteemed international journals. Additionally, he has showcased his erudition by crafting 6 insightful book chapters.

Dr. S. Murugan's commitment extends beyond research and publications. He has played a pivotal role in nurturing academic excellence by guiding 7 Ph.D. students and currently overseeing the mentorship of 7 promising Ph.D. scholars. His affiliations with prestigious organisations underscore his professional stature. Beyond academia, Dr. Murugan's endeavours in community health initiatives underscore his holistic approach to well-being. This showcases his commitment to fostering a positive impact beyond the academic sphere. His multifaceted contributions exemplify a distinguished educator, researcher, and advocate for community welfare.

Manikkoth, Shyamjith
Dr. Shyamjith Manikkoth is a devoted scholar in the field of Pharmacology, currently holding the esteemed position of Associate Professor at the Kanachur Institute of Medical Sciences in Mangalore. His academic and research voyage has been distinguished by an unwavering passion for delving into the intricacies of neuropharmacology and ethnopharmacology.

His professional trajectory is characterised by a rich tapestry of experiences. Dr. Manikkoth has undergone rigorous training in the intricate techniques of laboratory animal handling and has acquired proficiency in operating advanced instruments, including HPLC and Spectrophotometer. An outstanding milestone in his career was his pivotal role in establishing cutting-edge Ethnopharmacology and Neuropharmacology laboratories at Yenepoya University in Mangalore. Furthermore, he has contributed significantly to cost-effective enhancements of various pharmacological apparatus and instruments utilized in animal experiments.

Furthermore, he has contributed significantly to cost-effective enhancements of various pharmacological apparatus and instruments utilised in animal experiments. His research pursuits have been firmly grounded in the realms of Ethnopharmacology and Neuropharmacology, providing him with a profound insight into the captivating domains of traditional medicinal practices and the neurological facets of pharmacology. The zenith of Dr. Manikkoth's academic and research odyssey is eloquently mirrored in his portfolio of achievements. From probing the neuroprotective potential inherent in natural compounds to pioneering innovative teaching methodologies, his research journey has been a kaleidoscope of diversity and intellectual enrichment.

Vani, Chandrapragasam
Dr. C. Vani presently holds the esteemed position of Assistant Professor at the Karunya Institute of Technology and Sciences. Her academic and research journey stands as a testament to her unwavering commitment to the pursuit of knowledge and excellence.

Her academic voyage commenced at Nirmala College for Women in Coimbatore, where she earned her Bachelor's degree in Zoology. Driven by an insatiable thirst for knowledge, she continued her educational odyssey at Bharathiar University. Here, she achieved a Master's degree in Animal Sciences, followed by a Master of Philosophy (M.Phil) in Animal Sciences. The zenith of her academic journey was reached when she attained her Ph.D. in Biotechnological research.

Dr. Vani's contributions to the field have garnered recognition in the form of prestigious honours and awards. Notably, she has received sponsorship from the Department of Biotechnology and the Ministry of Science and Technology, enabling her to conduct training programs in the specialized domains of animal and plant tissue culture, as well as advanced techniques in animal cell culture. Her professional trajectory harmoniously aligns with her ongoing research endeavors, which primarily revolve around the exploration of bioactive compounds derived from Lactobacillus plantarum. These compounds hold promising potential as therapeutic agents for addressing the complex challenges posed by Alzheimer's Disease.