Pieters / McKinney Pathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism

2013
ISBN: 978-3-642-40231-9
Verlag: Springer

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Beschreibung

Mycobacterium tuberculosis is one of the most notorious pathogens on earth, causing the death of approximately 1.5 million people annually. A major problem in the fight against tuberculosis is the emergence of strains that have acquired resistance to all available antibiotics. One key to the success of M. tuberculosis as a pathogen is its ability to circumvent host immune responses at different levels. This is not only a result of the special makeup of M. tuberculosis in terms of genetic diversity and DNA metabolism and its possession of specialized secretion systems, but also of its ability to hijack the host’s innate immune defence mechanisms.

In this volume, researchers from different disciplines provide a topical overview of the diverse mechanisms that contribute to the virulence of M. tuberculosis, ranging from their genetic, metabolic and molecular makeup, as well as the complex strategies these bacteria utilize to escape immune destruction within infected hosts.

Autoren

Herausgeber

Pieters, Jean

McKinney, John D.

Inhaltsverzeichnis

Genetic Diversity in Mycobacterium tuberculosisSebastien Gagneux DNA Metabolism in Mycobacterial PathogenesisDigby F. Warner, Tone Tønjum and Valerie Mizrahi Molecular Biology of Drug Resistance in Mycobacterium tuberculosisTasha Smith, Kerstin A. Wolff, and Liem Nguyen Antimicrobial Efflux Pumps and Mycobacterium tuberculosis Drug Tolerance: Evolutionary ConsiderationsJohn D. Szumowski, Kristin N. Adams, Paul H. Edelstein, and Lalita Ramakrishnan Getting Across the Cell Envelope: Mycobacterial Protein SecretionAniek D. van der Woude, Joen Luirink, and Wilbert Bitter A Single-Cell Perspective on Non-Growing but Metabolically Active (NGMA) BacteriaGiulia Manina and John D. McKinney Mycobacterium tuberculosis Metabolism and Host Interaction: Mysteries and ParadoxesSabine Ehrt and Kyu Rhee Surviving the Macrophage: Tools and Tricks Employed by Mycobacterium tuberculosisRajesh Jayachandran, Somdeb BoseDasgupta and Jean Pieters Host-Pathogen Interactions During Mycobacterium tuberculosis InfectionsSarah Stanley and Jeffery S. Cox

Zielgruppe

Research

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