Inflammatory Disorders

2015
ISBN: 978-3-319-10011-1
Verlag: Springer International Publishing

Buch, Englisch, Band 839, 67 Seiten, HC runder Rücken kaschiert, Format (B × H): 183 mm x 260 mm, Gewicht: 366 g

Reihe: Advances in Experimental Medicine and Biology

The mechanistic basis of chronic inflammation remains unclear. The research sheds new light on the immune cells expressing the activation markers HLA-DR and regulatory T cells (Tregs) and the cells expressing Siglec receptors as being key players in the immune system responsiveness to antigens and thus in lung tissue damage of chronic inflammation. The results help understand the mechanisms of action of common drugs used in COPD, such as formoterol, tiotropium, or corticosteroids, and point to novel drug targets. The chapters also deal with brain damaging effects, by far unrecognized, of inhaled corticosteroid therapy, a time-proven management of chronic inflammatory airway conditions; asthma being a case in point. Novel methods, likely less producing side effects, of macrolide antibiotics administration by inhalation are discussed, emphasizing not only bacteriostatic but also anti-inflammatory action.

Zielgruppe

Research

Autoren/Hrsg.

Pokorski, Mieczyslaw

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Kardiologie, Angiologie, Phlebologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Public Health, Gesundheitsmanagement, Gesundheitsökonomie, Gesundheitspolitik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Pneumologie, Atmung, Asthma
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

Inhaled Corticosteroids Increase Siglec-5/14 Expression in Sputum Cells of COPD Patients.- Tregs and HLA-DR Expression in Sputum Cells of COPD Patients Treated with Tiotropium and Formoterol.- Inhalation of Macrolides: A Novel Approach to Treatment of Pulmonary Infections.- Influence of Denture Plaque Biofilm on Oral Mucosal Membrane in Patients with Chronic Obstructive Pulmonary Disease.- Biophysical Activity of Animal-Derived Exogenous Surfactants Mixed with Rifampicin.- Organic Changes in the Central Nervous System in Children on Chronic Inhaled Corticosteroid Therapy.- Stem Cell Experiments Moves into Clinic: New Hope for Children with Bronchopulmonary Dysplasia.- Soluble Ligand CD40 and Uric Acid as Markers of Atheromatosis in Patients with Obstructive Sleep Apnea.- Carotid Artery Intima-Media Thickness in Hypertensive Patients with Obstructive Sleep Apnea.