Polyploidization and Cancer

1. Auflage 2010
ISBN: 978-1-4419-6198-3
Verlag: Springer

Buch, Englisch, Band 676, 151 Seiten, Format (B × H): 176 mm x 259 mm, Gewicht: 442 g

Reihe: Advances in Experimental Medicine and Biology

Limiting genome replication to once per cell cycle is vital for maintaining genome stability. Although polyploidization is of physiologically importance for several specialized cell types, inappropriate polyploidization is believed to promote aneuploidy and transformation. A growing body of evidence indicates that the surveillance mechanisms that prevent polyploidization are frequently perturbed in cancers. Progress in the past several years has unraveled some of the underlying principles that maintain genome stability. This book brings together leaders of the field to overview
subjects relating to polyploidization and cancer.

Zielgruppe

Research

Autoren/Hrsg.

Poon, Randy Y C

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien

Inhaltsverzeichnis

Polyploidy, Aneuploidy and the Evolution of Cancer.- Molecular Mechanisms and Function of the Spindle Checkpoint, a Guardian of the Chromosome Stability.- Understanding Cytokinesis Failure.- DNA Damage and Polyploidization.- Role of the p53 Family in Stabilizing the Genome and Preventing Polyploidization.- Centrosomes, Polyploidy and Cancer.- Polyploidy: Mechanisms and Cancer Promotion in Hematopoietic and Other Cells.- Polyploidization of liver cells.- Analysis of Cellular DNA Content by Flow and Laser Scanning Cytometry.

Über Autor(innen)

Randy Y.C. Poon is a professor of Biochemistry at the Hong Kong University of Science and Technology. He was educated at Tonbridge School and received his Master of Arts degree from St. Catharine’s College at the University of Cambridge. He then studied for a Doctor of Philosophy degree at the University of Cambridge and Cancer Research UK with Tim Hunt, FR S. Dr. Poon conducted postdoctoral training at the Salk Institute with Tony Hunter, FR S. Dr. Poon is a member of Editorial Board of numerous international journals, including the Biochemical Journal and Cancer Biology and Therapy. His research interests focus on understanding the molecular basis of cell cycle control in normal and cancer cells.