Stereochemistry and Stereoselective Synthesis

An Introduction
1. Auflage 2016
ISBN: 978-3-527-33901-3
Verlag: Wiley VCH Verlag GmbH

Buch, Englisch, 265 Seiten, Format (B × H): 172 mm x 246 mm, Gewicht: 616 g

Dieses Lehrbuch aus der Feder anerkannter und erfahrener Autoren füllt ein Lücke. Endlich steht eine prägnante Einführung in Schlüsselkonzepte der organischen Stereochemie und in wichtige klassische sowie moderne Methoden der stereoselektiven Synthese zur Verfügung. Die Konzepte sind reichhaltig in Farbe illustriert. Praktische Beispiel sowie Frage-/Antwortabschnitte tragen zur Festigung der Lehrstoffes bei. Über die Wiley-Website sind Animationen verfügbar. Dieses Buch ist ein Muss für Studenten der Chemie, Biochemie und Biowissenschaften, für Forscher in Pharmaunternehmen und Firmen der Agrochemie, die eine schnelle Einführung in das Fachgebiet suchen.

Autoren/Hrsg.

Poppe, László

Nógrádi, Mihály

Nagy, József

Hornyánszky, Gábor

Boros, Zoltán

Fachgebiete

• Naturwissenschaften Chemie Physikalische Chemie
• Naturwissenschaften Chemie Organische Chemie
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie

Inhaltsverzeichnis

BASIC PRINCIPLES AT THE MOLECULAR LEVEL
1.) Structure and Properties
2.) Concepts of Stereochemistry
PROPERTIES AT THE LEVEL OF MOLECULAR SETS
3.) Time Scales, Conformational Changes
4.) Tautomerism
5.) Absolute Configuration
6.) Enantiomeric Composition
GENERAL CHARACTERISTICS OF SELECTIVE REACTIONS
7.) Main Types of Selectivities
8.) Classification of Selectivities
9.) Stereospecific and Stereoselective Reactions
10.) Applications of Stereoselective Reactions
11.) Stoichiometric Methods
12.) Catalytic Methods

Über Autor(innen)

Mihály Nógrádi is emeritus professor at Budapest University of Technology and Economics (BME), Hungary. He obtained his diploma at the Faculty of Chemistry at the Technical University of Budapest in 1957 and then became the head of the control laboratory at the pharmaceutical company EGyT (now Egis Pharmaceuticals PLC) in Budapest. In 1962 he joined the alkaloid chemistry group at the Technical University of Budapest. He completed his PhD under the supervision of Prof. L. Farkas in 1964 and prepared his "Candidate of Chemical Sciences" thesis in 1967. After spending one year at Sheffield University, UK, he became professor at Technical University of Budapest and was appointed scientifc advisor by the Hungarian Academy of Sciences. He retired in 1996 but retained his laboratory at BME until 2012. He has published 150 papers, authored two books and is coinventor of several patents (e.g. Osteochin© / Osten©, a drug against osteoporosis which was marketed in Japan and Hungary).
 
László Poppe is a professor at Budapest University of Technology and Economics (BME), Hungary. He graduated as a chemical engineer from Technical University of Budapest in 1983 and completed his PhD in organic chemistry with Prof. L. Novák in 1987. He then was a research fellow at the Central Research Institute for Chemistry of the Hungarian Academy of Sciences and spent one year (1991-1992) as an Alexander von Humboldt Fellow with Prof. J. Rétey at the University of Karlsruhe, Germany. He became professor and head of the Bioorganic Chemistry group at the Department of Organic Chemistry and Technology at BME in 2005. His research interests are centered on stereoselective synthesis of biologically active compounds, biocatalysis, and enzyme mechanisms.
 
József Nagy is a research fellow in the group of Prof. L. Poppe at Budapest University of Technology and Economics (BME), Hungary. He graduated as a chemical engineer and completed his PhD with Prof. J. Nyitray in 1980.
 
Gábor Hornyánszky is an associate professor at the Department of Organic Chemistry and Technology at Budapest University of Technology and Economics (BME), Hungary. After having obtained his PhD, he worked as postdoctoral fellow, and then became a researcher in the alkaloid chemistry group at BME. Currently he is working in the group of Prof. L. Poppe at BME. He is also the Head of the Dean's Office at the Faculty of Chemical Technology and Biotechnology.
 
Zoltán Boros is a reserch fellow of the group of Prof. L. Poppe at Budapest University of Technology and Economics (BME), Hungary. He graduated as a chemical engineer and completed his PhD with Prof. L. Poppe in 2014.