Protein Degradation in Health and Disease

Softcover Nachdruck of the original 1. Auflage 2002
ISBN: 978-3-642-62714-9
Verlag: Springer

Buch, Englisch, 130 Seiten, Format (B × H): 155 mm x 235 mm, Gewicht: 230 g

Reihe: Progress in Molecular and Subcellular Biology

Protein degradation has been identified as a major mechanism for the regulation of cellular functions. Not surprisingly, its deregulation is implied in almost any pathological condition. This book describes how aged proteins are eliminated during cell metabolism, how cell proliferation is regulated by protein degradation and how its deregulation can contribute to the development of cancer, how protein degradation is modified during normal and abnormal aging, in particular with regard to Alzheimer's disease and other degenerative diseases of the brain and central nervous system. Attempts aiming at correcting these pathologies by interfering with deviations of the normal pathway of protein degradation are also treated.

Zielgruppe

Research

Autoren/Hrsg.

Reboud-Ravaux, Michele

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Naturwissenschaften Biowissenschaften Zellbiologie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)

Inhaltsverzeichnis

Roles of SCF and VHL Ubiquitin Ligases in Regulation of Cell Growth.- Aging of Proteins and the Proteasome.- Protein Degradation in the Aging Organism.- Protein Degradation in Alzheimer’s Disease and Aging of the Brain.- Protein Degradation in Human Disease.- The 26S Proteasome.- Proteasome Inhibitors.