Biophysics of RNA Folding

2013
ISBN: 978-1-4899-8894-2
Verlag: Springer

Buch, Englisch, Band 3, 238 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 3752 g

Reihe: Biophysics for the Life Sciences

This volume, written by experts in the field, discusses the current understanding of the biophysical principles that govern RNA folding, with featured RNAs including the ribosomal RNAs, viral RNAs, and self-splicing introns. In addition to the fundamental features of RNA folding, the central experimental and computational approaches in the field are presented with an emphasis on their individual strengths and limitations, and how they can be combined to be more powerful than any method alone; these approaches include NMR, single molecule fluorescence, site-directed spin labeling, structure mapping, comparative sequence analysis, graph theory, course-grained 3D modeling, and more. This volume will be of interest to professional researchers and advanced students entering the field of RNA folding.

Zielgruppe

Research

Autoren/Hrsg.

Russell, Rick

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
• Naturwissenschaften Physik Angewandte Physik Biophysik
• Naturwissenschaften Biowissenschaften Angewandte Biologie Biophysik

Inhaltsverzeichnis

Introduction.- Comparative Analysis of the Higher-order Structure of RNA.- Graph Applications to RNA Structure and Function.- Prediction and Coarse-Grained Modeling of RNA Structures.- RNA Folding Using Site-Directed Spin Labeling.- The RNA Recognition Motif and Messenger RNA.- Memory Effects in RNA folding dynamics revealed by single molecule fluorescence.- An integrated picture of HDV ribozyme catalysis.- Combining biochemical and structural information to model RNA-protein complex assembly.- Following RNA Folding From Local and Global Perspectives.- The Roles of Chaperones in RNA Folding.