Silvestri / Lichterfeld | HIV-1 Latency | Buch | sack.de

Silvestri / Lichterfeld HIV-1 Latency



1. Auflage 2018, Band: 417, 248 Seiten, Gebunden, Book, Format (B × H): 159 mm x 248 mm, Gewicht: 534 g Reihe: Current Topics in Microbiology and Immunology
ISBN: 978-3-030-02815-2
Verlag: Springer, Berlin


Silvestri / Lichterfeld HIV-1 Latency

This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.

Zielgruppe


Research

Weitere Infos & Material


Molecular Control of HIV and SIV Latency.- Assays to Measure Latency, Reservoirs and Reactivation.- The Antiviral Immune Response and its Impact on the HIV-1 Reservoir.- Nonhuman Primate Models for Studies of AIDS Virus Persistence During Suppressive Combination Antiretroviral Therapy.- SIV Latency in Macrophages in the CNS.- Mathematical models of HIV latency.- Residual Immune Activation and Latency.- Immune Interventions to Eliminate the HIV Reservoir.- Cell and Gene Therapy for HIV Cure.


Silvestri, Guido
Guido Silvestri
Emory University School of Medicine, Atlanta, GA 30329, USAgsilves@emory.edu
Mathias LichterfeldThe Brigham and Women's Hospital and the Ragon Institute of MGH, MIT and Harvard, Boston, MA, USAMLICHTERFELD@mgh.harvard.edu



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