Silvestri / Lichterfeld | HIV-1 Latency | Buch |

Silvestri / Lichterfeld HIV-1 Latency

1. Auflage 2018, Band: 417, 248 Seiten, Gebunden, Book, Format (B × H): 159 mm x 248 mm, Gewicht: 534 g Reihe: Current Topics in Microbiology and Immunology
ISBN: 978-3-030-02815-2
Verlag: Springer, Berlin

Silvestri / Lichterfeld HIV-1 Latency

This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.



Weitere Infos & Material

Molecular Control of HIV and SIV Latency.- Assays to Measure Latency, Reservoirs and Reactivation.- The Antiviral Immune Response and its Impact on the HIV-1 Reservoir.- Nonhuman Primate Models for Studies of AIDS Virus Persistence During Suppressive Combination Antiretroviral Therapy.- SIV Latency in Macrophages in the CNS.- Mathematical models of HIV latency.- Residual Immune Activation and Latency.- Immune Interventions to Eliminate the HIV Reservoir.- Cell and Gene Therapy for HIV Cure.

Silvestri, Guido
Guido Silvestri
Emory University School of Medicine, Atlanta, GA 30329,
Mathias LichterfeldThe Brigham and Women's Hospital and the Ragon Institute of MGH, MIT and Harvard, Boston, MA,


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