Flavonoids and Related Compounds

Bioavailability and Function
1. Auflage 2012
ISBN: 978-1-4398-4826-5
Verlag: CRC Press

Buch, Englisch, 471 Seiten, Format (B × H): 161 mm x 240 mm, Gewicht: 869 g

Reihe: Oxidative Stress and Disease

Flavonoids exert a multiplicity of biological effects on humans and can have beneficial implications for numerous disease states. Flavonoids and Related Compounds: Bioavailability and Function examines current knowledge regarding the absorption, metabolism, and bioavailability of individual flavonoids and related phenolic compounds.

Profiling the latest evidence of their impact on various human pathological conditions, the book summarizes current thinking with regard to the biotransformation and conjugation of individual compounds in the gastrointestinal tract, liver, large intestine, and cells. It highlights a topic that has been largely ignored—namely the extent to which dietary phenolics components undergo metabolism in the large intestine. It also explores the generation of bacterially derived metabolites. Individual chapters discuss which metabolites enter the circulatory system and are likely to offer protective actions against human diseases.

Edited by internationally recognized leaders in the field, the book presents contributions by a panel of experts who demonstrate the potential of flavonoids in ameliorating a range of disease states, including cardiovascular disease, Alzheimer’s and Parkinson’s disease and other neurodegenerative disorders, and cancer. The research presented in this volume provides a reliable starting point for further inquiry and experimentation.

Zielgruppe

Nutritionists, biochemists, physiologists, neurologists, and medical scientists interested in diet and health.

Autoren/Hrsg.

Spencer, Jeremy P. E.

Crozier, Alan

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Ernährungsmedizin, Diätetik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Komplementäre Medizin, Asiatische Medizin (TCM), Heilpraktiker
• Naturwissenschaften Chemie Organische Chemie Biochemie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Physiologie
• Naturwissenschaften Chemie Analytische Chemie Umweltchemie, Lebensmittelchemie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft

Inhaltsverzeichnis

Bioavailability of Flavanones. Bioavailability of Dietary Monomeric and Polymeric Flavan-3-ols. Anthocyanins: Understanding Their Absorption and Metabolism. Bioavailability of Flavonols and Flavones. Bioavailability of Isoflavones in Humans. Dietary Hydroxycinnamates and Their Bioavailability. Bioavailability of Dihydrochalcones. Occurrence, Bioavailability, and Metabolism of Resveratrol. Bioavailability and Metabolism of Ellagic Acid and Ellagitannins. Colon-Derived Microbial Metabolites of Dietary Phenolic Compounds. Synthesis of Dietary Phenolic Metabolites and Isotopically Labeled Dietary Phenolics. Interactions of Flavan-3-ols Within Cellular Signaling Pathways. Flavonoids and Vascular Function. Effects of Flavonoids on the Vascular Endothelium: What Is Known and What Is Next?. Green Tea Flavan-3-ols and Their Role in Protecting Against Alzheimer’s and Parkinson’s Disease Pathophysiology. Flavonoids and Neuroinflammation. Effects of Flavonoids on Cognitive Performance. Flavonoids and Oral Cancer. Flavonoids and Cancer—Effects on DNA Damage. Index.

Über Autor(innen)

Jeremy P. E. Spencer received his PhD degree from King’s College London in 1997 and is currently Professor of Nutritional Medicine at the University of Reading. His initial work focused on the cellular and molecular mechanisms underlying neuronal death in Parkinson’s and Alzheimer’s diseases. His recent interests concern how flavonoids influence brain health through their interactions with specific cellular signaling pathways pivotal in protection against neurotoxins, in preventing euroinflammation, and in controlling memory, learning, and neurocognitive performance.

Alan Crozier graduated from the University of Durham in the UK, and after completing postgraduate studies at the University of London, he moved to a postdoctoral position at the University of Calgary in Alberta. He is currently a Senior Research Fellow at the University of Glasgow, working in the area of dietary flavonoids and phenolics. His research group has extensive national and international collaborations and is focused principally on teas, coffee, fruit juices, and wines, and the absorption and metabolism of a diversity of potentially protective polyphenolic compounds in the body.