Spickett / Forman Lipid Oxidation in Health and Disease

Erscheinungsjahr 2015
ISBN: 978-1-4822-0286-1
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 440 Seiten

Reihe: Oxidative Stress and Disease

Many balanced cellular responses depend on lipid molecular structure and reactivity of lipid oxidation products as well as their concentration, and determine the outcome of physiological signaling versus disease pathology. This book covers both established information and recent findings on the action of oxidized lipid products on cell signaling and gene expression in health and disease. It is composed of three sections: (1) Chemistry and Biochemistry of Lipid Oxidation, (2) Sites of Biological Actions of Oxidized Lipids, and (3) Oxidized Lipids in Pathology and Disease.

Autoren/Hrsg.

Spickett, Corinne M.

Forman, Henry Jay

Fachgebiete

• Naturwissenschaften Biowissenschaften Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Endokrinologie
• Naturwissenschaften Biowissenschaften Molekularbiologie

Inhaltsverzeichnis

Introduction – What is lipid oxidation generally (peroxidation, nitration, chlorination)

Chemistry and Biochemistry of Lipid Oxidation
Non-enzymatic mechanisms of lipid oxidation
Enzymatic mechanisms of lipid oxidation
Lipid oxidation by myeloperoxidase and related enzymes
Formation of nitrated lipids and phospholipids and their biological relevance
Biological protection against lipid oxidation
Lipoxidation – Formation of adducts between ox lipids / PLs and proteins

Sites of Biological Actions of Oxidized Lipids
Do Toll-like receptors mediate effects of oxidized phospholipids?
The role of PPARs in responses to oxidized lipids
Scavenger receptors and oxidized lipids / PLs as DAMPs
Oxidized and nitrated lipid interactions with Nrf2-KEAP-1

Oxidized Lipids in Pathology and Disease
Analysis of lipid oxidation products in health and disease
Pro-inflammatory versus anti-inflammatory effects of oxidized phospholids
Beneficial roles of oxidized lipids in resolution of inflammation: resolvins
The role of oxidized phospholipids in atherosclerosis
Oxidized lipid products contribute to carcinogenesis
The role of lipid oxidation in the neurodegenerative diseases mechanisms
Oxidized lipids in metabolic disorders
Oxidized lipids in lupus and rheumatoid disease