roleofsensorynervesinotherpathologicalconditions. Severalcommonthemes willemergeinthispart,includingthemodeofsensorynerveactivationinvarious tissues and organs, the alterations in sensory nerve excitability associated with disease,andtheimportanceofin?ammationandin?ammatorymediatorsininiti- ingalteredsensorynervefunctionindisease. v vi Preface Whilstthe?rstpartfocusesontheclinicaland/orsystemsphysiology,PartIIhas itsfocusatthecellandmolecularlevel. Thisparthighlightsthecurrentundersta- ingofproteins/ionchannels/mediatorsthathavecreatedthemostintenserecent interestintheareaofsensorynervebiology. Together,thesechapterswillgivethe reader important knowledge about how sensory nerve function can be altered pharmacologically. Thelastchapterinthispartdescribestheprocessesthatgive risetoalteredneuralre?exesatthecentrallevel. Themechanismsdescribedin thesechaptersreinforcetheroleofproteins/mediatorshighlightedinthepreceding chapters. Theroleofthesecellular,molecularandphysiologicalprocessesinthe diseasesdiscussedinPart1areemphasized. TheaimofPartIIIistohighlightpotentialdrugtargetsthatmightaltersensory nervefunction. Mostoftheworkhasbeendevotedtothetreatmentofneuropathic painandsothispartheavilyemphasizesthissubject. However,aswillbeapparent fromPartI,manyofthesetargetscouldbeutilizedinothertherapeuticareasthat implicatesensorynervesintheirpathophysiologicalprocesses. Thefocusofthe chaptersisonopioidsandmodulatorsofionchannelsandthenthe?nalchapteris devotedtofuturetreatmentstrategiesforneuropathicpain. Finally,wewouldliketothankallthecontributors,includingco-authors,who agreedtowritechaptersforthisbookandthepublishers,especiallySusanneDathe, fortheirpatienceandassistance. Baltimore B. J. Canning London D. Spina Contents PartI RoleofSensoryNervesinDisease NeuropathicPain:AClinicalPerspective. 3 RalfBaron VisceralPain:TheNeurophysiologicalMechanism. 31 JyotiN. Sengupta Migraine. 75 SilviaBenemei,PaolaNicoletti,JayG. Capone,Francesco DeCesaris,andPierangeloGeppetti AfferentNerveRegulationofBladderFunctioninHealth andDisease. 91 WilliamC. deGroatandNaokiYoshimura SensoryNervesandAirwayIrritability. 139 B. J. CanningandD. Spina RegulationofCardiacAfferentExcitabilityinIschemia. 185 Liang-WuFuandJohnC. Longhurst RolesofGastro-oesophagealAfferentsintheMechanisms andSymptomsofRe?uxDisease. 227 AmandaJ. PageandL. AshleyBlackshaw PartII CellandMolecularMechanismsRegulatingSensory NerveFunction TransientReceptorPotentialChannelsonSensoryNerves. 261 S. R. EidandD. N. Cortright Acid-SensitiveIonChannelsandReceptors. 283 PeterHolzer PurinesandSensoryNerves. 333 GeoffreyBurnstock vii viii Contents Sensory-Nerve-DerivedNeuropeptides: PossibleTherapeuticTargets. 393 ElizabethS. Fernandes,SabineM. SchmidhuberandSusanD. Brain CytokineandChemokineRegulationofSensory NeuronFunction. 417 RichardJ. Miller,HosungJung,SoniaK. BhangooandFletcherA. White TheRoleofPeptidesinCentralSensitization. 451 V. S. Seybold PartIII CurrentandFutureTreatmentStrategiesTargeting SensoryNerves OpioidsandSensoryNerves. 495 ChristophSteinandChristianZöllner ThePharmacologyofVoltage-GatedSodiumChannels inSensoryNeurones. 519 ReginaldJ. DochertyandClareE. Farmer RoleofCalciuminRegulatingPrimarySensory NeuronalExcitability. 563 T. D. Gover,T. H. MoreiraandD. Weinreich FutureTreatmentStrategiesforNeuropathicPain. 589 FabienMarchand,NicholasG. JonesandStephenB.
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Weitere Infos & Material
Role of sensory nerves in disease.- Neuropathic Pain: A Clinical Perspective.- Visceral Pain: The Neurophysiological Mechanism.- Migraine.- Afferent Nerve Regulation of Bladder Function in Health and Disease.- Sensory Nerves and Airway Irritability.- Regulation of Cardiac Afferent Excitability in Ischemia.- Roles of Gastro-oesophageal Afferents in the Mechanisms and Symptoms of Reflux Disease.- Cell and molecular mechanisms regulating sensory nerve function.- Transient Receptor Potential Channels on Sensory Nerves.- Acid-Sensitive Ion Channels and Receptors.- Purines and Sensory Nerves.- Sensory-Nerve-Derived Neuropeptides: Possible Therapeutic Targets.- Cytokine and Chemokine Regulation of Sensory Neuron Function.- The Role of Peptides in Central Sensitization.- Current and Future treatment strategies targeting sensory nerves.- Opioids and Sensory Nerves.- The Pharmacology of Voltage-Gated Sodium Channels in Sensory Neurones.- Role of Calcium in Regulating Primary Sensory Neuronal Excitability.- Future Treatment Strategies for Neuropathic Pa.
