Oxidation: The Cornerstone of Carcinogenesis

Oxidation and Tobacco Smoke Carcinogenesis. A Relationship Between Cause and Effect
1. Auflage. Softcover version of original hardcover Auflage 2008
ISBN: 978-90-481-7702-8
Verlag: Springer Netherlands

Buch, Englisch, 258 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 429 g

In order to learn oncology, it is necessary to acquire a comprehensive knowledge of molecular biology in carcinogenesis, and then, with this as a background, to consider the principles of the theoretical and clinical basis of the subject. For graduate students who are preparing themselves for the specialty of internal medicine or clinical oncology, and physicians who wish to become proficient in oncology, it is exceedingly difficult to be highly skilled and completely informed in this expanding field of science without a comprehensive text on the subject. This book is unique, due to its collective approach to the key aspects of the interdependency between three entities: oxidative stress, tobacco smoke and carcinogenesis, operating in a cause-effect sequence, in a concise and to the point manner. I hope this book will prove to be a helpful companion to the internist, the oncologist and the research scientist in molecular biology as well as a work of reference for the general practitioner and physician interested in cancer research.

Zielgruppe

Research

Autoren/Hrsg.

Stavridis, John C.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Naturwissenschaften Biowissenschaften Molekularbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung

Inhaltsverzeichnis

Oxygen and Nitrogen Free Radicals.- Oxidative Stress.- Oxidative Damage of Genome DNA: Repair Mechanisms.- Mitochondria: Structure, Function and Relationship with Carcinogenesis.- Oxidative Activation of Transcription Factor Pathways by Cigarette Smoke Oxidants.- Cell Protection Mechanisms from Oxidation.- Role of DNA Adducts in Carcinogenesis.- Transmolecular Reactions of Genetic Toxicity: Alkylation and Methylation of DNA.- Toxicity and Carcinogenicity of Hydrocarbons.- Toxicity and Carcinogenicity of the Aromatic Hydrocarbons.- Toxicity and Carcinogenicity of Aldehydes.- Toxicity and Carcinogenicity of the Nitriles.- Toxicity and Carcinogenicity of the Eterocyclic Organic Compounds.- Toxicity and Carcinogenicity of Metals.- Oxidative Profile of Cigarette Smoke and Lung Cancer.- Smoking and Lung Cancer.

Über Autor(innen)

John C. Stavridis is a medical doctor who studied Medicine at the Military Medical School of Thessaloniki, Greece. He specialized in Internal Medicine at the Evangelismos Medical Centre, Athens, and received his MD and Professorship from the University of Athens Medical School. Following a postdoctoral position as a senior research fellow and registrar at postgraduate Medical School, London University, Hammersmith Hospital, Department of Clinical Hematology, he joined the Hematology Unit at St. Sabbas Anticancer Hospital, Athens, as director. He taught Physiology from 1991-1999 as a head of the Department of Physiology and full professor at the University of Athens Medical School. Since 1999, Prof. Stavridis has been President of the Institute of Biomedical Research and Biotechnology, Athens.